2026-09-23T15:51:58.778319Z http://oai.impactu.colav.co/oai

oai:impactu.colav.co:6a457e895418a51e32f79100 2026-07-03T06:21:20Z

http://purl.org/coar/resource_type/c_6501 EN 1964-05-01 107 5 442 442 10.1001/archpedi.1964.02080060444003 https://pubmed.ncbi.nlm.nih.gov/14120408 0002-922X 2374-3018 https://openalex.org/W2076337061 Rajasuriya K https://openalex.org/A5012151411 Parathyroid Disorders and Treatments Nephrology Medicine Health Sciences Genetic Syndromes and Imprinting Pancreatic and Hepatic Oncology Research Ever since Sandstrom 1 discovered the parathyroid glands a large amount of literature has accumulated regarding the function of these glands in health and disease. Felix Mandl 2 was the first to remove successfully an adenoma of the parathyroid glands, which he accomplished in the now famous case of the Viennese streetcar conductor. Several cases of parathyroid adenoma occurring in adults have now been recorded and presently the diagnosis is made quite confidently. Parathyroid adenoma occurring in children and adolescents under the age of 15 years, is however, an extreme rarity. Wilkins 3 reviewing the literature was able to record only ten cases of primary hyperparathyroidism due to parathyroid adenoma in the age group below 15 years. Anspach and Clifton 4 were able to collect the same ten cases of parathyroid adenoma proved either at autopsy or operation in the age group referred to. Since 1939, we have been unable http://purl.org/coar/access_right/c_16ec

oai:impactu.colav.co:6a457e8d5418a51e32f79101 2026-07-03T06:21:20Z

http://purl.org/coar/resource_type/c_6501 EN 1988-11-01 124 11 1649 1655 10.1001/archderm.124.11.1649 0003-987X 1538-3652 https://openalex.org/W4255301836 Falabella Rafael https://openalex.org/A5036793477 American Medical Association American Medical Association melanin and skin pigmentation Cell Biology Biochemistry, Genetics and Molecular Biology Life Sciences Vitiligo Medicine Dermatology Surgery RNA regulation and disease • Autologous minigrafting has been reported as an effective method for repigmenting diverse types of stable leukoderma. A group of 22 patients with localized vitiligo, 17 segmental and five focal, who are under treatment with this method, are described. Thirteen patients attained a 90% to 100% repigmentation, two others achieved a partial improvement, and five patients had a positive test area indicating the possibility of repigmentation by means of this procedure. Only two patients had a negative test with minigrafts and, consequently, they were left untreated. Autologous minigrafting is suggested as an alternative for treating localized vitiligo, particularly when other medical therapeutic attempts have failed in repigmenting this often refractory condition. (<i>Arch Dermatol</i>1988;124:1649-1655) http://purl.org/coar/access_right/c_16ec

oai:impactu.colav.co:6a457e8d5418a51e32f79102 2026-07-03T06:21:20Z

http://purl.org/coar/resource_type/c_6501 EN 1956-09-01 56 3 426 428 10.1001/archopht.1956.00930040434010 https://pubmed.ncbi.nlm.nih.gov/13361615 1538-3601 0003-9950 https://openalex.org/W2163651408 Barraquer Moner José Ignacio https://openalex.org/A5081732722 American Medical Association American Medical Association Corneal Surgery and Treatments Radiology, Nuclear Medicine and Imaging Medicine Health Sciences Fibrous joint Enhanced Data Rates for GSM Evolution Cornea Ophthalmology Surgery Computer science Artificial intelligence Corneal surgery and disorders Intraocular Surgery and Lenses In full-thickness keratoplasty, with cylindrical graft, the majority of the mechanical postoperative complications are consequences of bad coaptation of the graft, due to some defect in the section or in the fixation. The use of instruments of first quality and the edge-to-edge suture have nearly eliminated them.¹ At first fixation was accomplished in 4 mm. grafts by using the sharp and very polished Vogt's suture needles, manufactured by Grieshaber and threaded with 000000 silk; placing two points at the extremes of the vertical meridian and progressively increasing its number until they are equal or even superior to the number of millimeters of the diameter of the graft.² The "sharp side," on Vogt's needle, has been modified to place it in the convexity, in order to safeguard the bridge of the tissue at each side of the wound,³which is attempted to be joined with the suture, making http://purl.org/coar/access_right/c_16ec

oai:impactu.colav.co:6a457e8e5418a51e32f79103 2026-07-03T06:21:20Z

http://purl.org/coar/resource_type/c_6501 EN 2008-11-03 10 6 429 431 10.1001/archfaci.10.6.429 https://pubmed.ncbi.nlm.nih.gov/19018070 1521-2491 1538-3660 https://openalex.org/W2069000615 Cobo Roxana https://orcid.org/0000-0002-3658-6256 https://openalex.org/A5001531203 Reconstructive Facial Surgery Techniques Surgery Medicine Health Sciences Subspecialty Plastic surgery Specialty Otorhinolaryngology Excellence Certification General surgery Reconstructive surgery Family medicine Management Law Political science Economics Nasal Surgery and Airway Studies Head and Neck Surgical Oncology Throughout the ages, people have always yearned to be attractive. The development of modern facial plastic surgery began over 100 years ago and was greatly advanced during World War I owing to the need to reconstruct the injuries inflicted on many of the soldiers who survived during this period. Otolaryngology worldwide includes facial plastic surgery within its training programs, and in many countries it has also become an important subspecialty.Facial plastic surgery is defined as the surgical specialty that focuses on http://purl.org/coar/access_right/c_16ec

oai:impactu.colav.co:6a457e8e5418a51e32f79104 2026-07-03T06:21:20Z

http://purl.org/coar/resource_type/c_6501 EN 1987-11-01 105 11 1522 1523 10.1001/archopht.1987.01060110068033 https://pubmed.ncbi.nlm.nih.gov/3675284 1538-3601 0003-9950 https://openalex.org/W2007909274 Amigó Rodríguez Alfredo https://openalex.org/A5074460707 Cortés‐Gutiérrez Elva https://orcid.org/0000-0002-5025-1284 https://openalex.org/A5016230151 Alvira Gustavo https://openalex.org/A5002589980 American Medical Association American Medical Association Ophthalmology and Visual Impairment Studies Epidemiology Medicine Health Sciences Lens (geology) Optometry Ophthalmology Optics Physics Corneal surgery and disorders Clear lens extraction is a refractive surgery used to compensate axial myopia. Formerly, intracapsular lens extraction was performed, but the present surgical method is extracapsular lens extraction or phacoemulsification. Clear lens extraction is becoming controversial because of the danger of complications. We retrospectively reviewed the postoperative complications in 33 eyes of 20 patients who underwent clear lens extraction at other institutions between 1966 and 1984. Twelve patients (60%) had motility disturbances. Eight (24%) of 33 eyes suffered secondary glaucoma; ten (30%), retinal detachment; 12 (36%), lens remnants in the pupillary space; and six (18%), blindness caused by clear lens extraction or by additional surgery performed by us while attempting to improve a poor prognosis. Clear lens extraction appears to be contraindicated in the young, in those with axial diameters greater than 29 mm, and in those presenting with peripheral chorioretinal degeneration. Moreover, clear lens extraction does not avoid the progression of myopia at the posterior segment. We suggest the use of safer, noninvasive, reversible alternatives. http://purl.org/coar/access_right/c_16ec

oai:impactu.colav.co:6a457e8e5418a51e32f79105 2026-07-03T06:21:20Z

http://purl.org/coar/resource_type/c_6501 EN 1977-11-01 34 11 694 694 10.1001/archneur.1977.00500230064011 1538-3687 0003-9942 https://openalex.org/W2037353913 Toro Gabriel https://openalex.org/A5110069664 American Medical Association American Medical Association Peripheral Neuropathies and Disorders Neurology Medicine Health Sciences Rabies Vaccination Pediatrics Leukoencephalopathy Encephalitis Internal medicine Immunology Pathology Virus Disease Infectious Encephalopathies and Encephalitis Rabies epidemiology and control • Twenty-one cases of neuroparalytic accidents of rabies vaccination (with suckling mouse brain vaccine), 11 of them fatal, were observed, occurring predominantly in men; the mean age of the patients was 29 years. On the average, 13 doses of the vaccine were used. Only three patients received less than seven doses. The mean latent period was 14 days (range, 4 to 24 days). In 16 patients (76%), a Guillain-Barré syndrome occurred that was moderate in three, severe in seven, and fatal in six. Pathologically, this was shown to be a typical polyradiculoneuritis. Five patients had fatal involvement of the central nervous system. Three had an acute disseminated perivenous leukoencephalopathy, with concurrent rabies encephalitis in one case. One patient had a perivenous myeloradiculopathy and one a chronic encephalomyelopathy of six years' duration with demyelinating plaques in the periventricular white matter, cerebellum, and spinal cord. Since the reduction of postexposure rabies vaccination to seven doses, no new cases have been observed in Colombia. http://purl.org/coar/access_right/c_16ec

oai:impactu.colav.co:6a457e8e5418a51e32f79106 2026-07-01T20:54:37Z

http://purl.org/coar/resource_type/c_6501 ES 1967-01-01 57 25 193 196 10.1001/archopht.1957.00930050827003 https://openalex.org/W13423944 Martín Payo Jesús San https://openalex.org/A5014403934 Political Theory and Democracy Political Science and International Relations Social Sciences Political science Social Sciences and Policies http://purl.org/coar/access_right/c_16ec

oai:impactu.colav.co:6a457e8e5418a51e32f79107 2026-07-03T06:21:20Z

http://purl.org/coar/resource_type/c_6501 EN 1988-11-01 124 11 1649 1649 10.1001/archderm.1988.01670110009002 https://pubmed.ncbi.nlm.nih.gov/3052304 0003-987X 1538-3652 https://openalex.org/W2039149220 Falabella Rafael https://openalex.org/A5036793477 American Medical Association American Medical Association melanin and skin pigmentation Cell Biology Biochemistry, Genetics and Molecular Biology Life Sciences Vitiligo Medicine Dermatology Refractory (planetary science) Medical treatment Surgery Family medicine Astrobiology Physics Biochemical Analysis and Sensing Techniques Skin Protection and Aging Autologous minigrafting has been reported as an effective method for repigmenting diverse types of stable leukoderma. A group of 22 patients with localized vitiligo, 17 segmental and five focal, who are under treatment with this method, are described. Thirteen patients attained a 90% to 100% repigmentation, two others achieved a partial improvement, and five patients had a positive test area indicating the possibility of repigmentation by means of this procedure. Only two patients had a negative test with minigrafts and, consequently, they were left untreated. Autologous minigrafting is suggested as an alternative for treating localized vitiligo, particularly when other medical therapeutic attempts have failed in repigmenting this often refractory condition. http://purl.org/coar/access_right/c_16ec

oai:impactu.colav.co:6a457e8e5418a51e32f79108 2026-07-03T06:21:20Z

http://purl.org/coar/resource_type/c_6501 EN 1990-04-01 47 4 382 382 10.1001/archneur.1990.00530040022012 1538-3687 0003-9942 https://openalex.org/W1992755473 Lechín Fuad https://openalex.org/A5109322210 American Medical Association American Medical Association Trigeminal Neuralgia and Treatments Pathology and Forensic Medicine Medicine Health Sciences Pimozide Trigeminal neuralgia Serotonergic Neurochemical Clonidine Refractory (planetary science) Anesthesia Neuroscience Psychology Internal medicine Haloperidol Serotonin Biology Dopamine Receptor Astrobiology Epilepsy research and treatment Neurosurgical Procedures and Complications <h3>In Reply.</h3> —We agree with Ecker's comments as to standard labeling of trigeminal neuralgia or, what he calls "classic... tic douloureux."¹Nonetheless, we have treated atypical as well as classic patients (not included in our double-blind study), with results similar to those that appeared in our article, where we only included those patients who had no periods of spontaneous remission; no refractory periods were observed either. Normally, we use doses much lower than required for a double-blind study, thus reducing side effects considerably. In our opinion, pain location and projections correspond to involvement of distinct central topographical areas of the brain-stem sensory trigeminal nuclear complex²related to the same neurochemical disorders: namely, a deficiency of central serotonergic activity. Following this trend, we have used different neuropharmacological manipulations, ie, a combination of drugs that interfere with central noradrenergic transmission (75 μg of clonidine plus 5 mg of levopromazine or http://purl.org/coar/access_right/c_16ec

oai:impactu.colav.co:6a457e8e5418a51e32f79109 2026-07-01T20:54:04Z

http://purl.org/coar/resource_type/c_6501 EN 1997-04-01 133 4 451 451 10.1001/archderm.1997.03890400051007 https://pubmed.ncbi.nlm.nih.gov/9126008 0003-987X 1538-3652 https://openalex.org/W2025244544 Enrique Acosta Álvaro https://openalex.org/A5101046511 American Medical Association American Medical Association Body Contouring and Surgery Surgery Medicine Health Sciences Cancer Lidocaine Clinical trial Anesthesia Internal medicine Dermatologic Treatments and Research Facial Rejuvenation and Surgery Techniques The TAT in skin cancer reconstructive surgery offers good results and minimal complications. http://purl.org/coar/access_right/c_16ec

oai:impactu.colav.co:6a457e8e5418a51e32f7910a 2026-07-04T13:05:46Z

http://purl.org/coar/resource_type/c_6501 EN 2011-11-28 171 21 1939 1939 10.1001/archinternmed.2011.530 https://pubmed.ncbi.nlm.nih.gov/22123804 0003-9926 1538-3679 https://openalex.org/W2147157007 Alía Inmaculada https://openalex.org/A5109271709 Molina Saldarriaga Francisco Jose https://orcid.org/0000-0002-2059-3400 35070006300 https://openalex.org/A5013436243 https://openalex.org/A5073327093 https://openalex.org/A5100625960 American Medical Association American Medical Association Respiratory Support and Mechanisms Pulmonary and Respiratory Medicine Medicine Health Sciences Mechanical ventilation COPD Exacerbation Intensive care unit Acute exacerbation of chronic obstructive pulmonary disease Placebo Randomized controlled trial Intubation Corticosteroid Population Anesthesia Internal medicine Environmental health Pathology Alternative medicine Intensive Care Unit Cognitive Disorders Chronic Obstructive Pulmonary Disease (COPD) Research clinicaltrials.gov Identifier: NCT01281748. http://purl.org/coar/access_right/c_16ec

oai:impactu.colav.co:6a457e8e5418a51e32f7910b 2026-07-03T06:21:19Z

http://purl.org/coar/resource_type/c_6501 SK 1977-02-01 113 2 234 234 10.1001/archderm.1977.01640020106022 https://pubmed.ncbi.nlm.nih.gov/138394 0003-987X 1538-3652 https://openalex.org/W2013549087 Londoño F https://openalex.org/A5047963954 Patarroyo Murillo Manuel Elkin https://orcid.org/0000-0002-1119-6040 7102918885 https://openalex.org/A5042652382 American Medical Association American Medical Association Leprosy Research and Treatment Infectious Diseases Medicine Health Sciences Erythema nodosum Dermatology Immunoglobulin D Pathogenesis Immunology Erythema Antibody Pathology Disease B cell Peripheral Neuropathies and Disorders Chronic Lymphocytic Leukemia Research <h3>To the Editor.—</h3> The publication of a work by Rea and Levan (111:1575, 1975) in which they discuss the pathogenesis of erythema nodosum leprosum and make a broad bibliographical review in which we couldn't find any reference to findings similar to ours, moves us to send a preliminary communication on the results of the work that we are performing on this subject. Since it has been considered that the most probable cause of erythema nodosum leprosum is a type III immunological response (Arthus phenomenon), and IgG deposits in the walls of vessels have been described,^1,2we wanted to know which of the four known IgG subclasses were responsible for the phenomenon. For this purpose, using direct inmunofluorescence, we made studies in 19 patients utilizing fluoresceinated antisera against IgG1, IgG2, IgG3, IgG4, IgM, IgD, IgA, and C3. In 14 of the 19 patients we found C3 deposits in the walls http://purl.org/coar/access_right/c_16ec

oai:impactu.colav.co:6a457e8e5418a51e32f7910c 2026-07-01T20:54:04Z

http://purl.org/coar/resource_type/c_6501 HT 1979-02-01 36 2 119 119 10.1001/archneur.1979.00500380089020 1538-3687 0003-9942 https://openalex.org/W2033933953 Román Gustavo https://orcid.org/0000-0002-5429-445X https://openalex.org/A5102930901 Del Toro G https://openalex.org/A5041488382 American Medical Association American Medical Association Malaria Research and Control Public Health, Environmental and Occupational Health Medicine Health Sciences Cerebral Malaria Malaria Pathogenesis Cerebral circulation Immunology Immune system Vascular permeability Biology Pathology Plasmodium falciparum Internal medicine Digital Imaging for Blood Diseases <h3>In Reply.—</h3> We did mention sludging of the circulation and "plugging" of the cerebral capillaries by clumped erythrocytes among the numerous factors that have been implicated in the pathogenesis of cerebral malaria, although inadvertently, no reference to the pioneer work of Knisely et al^1-4was made. We also referred to the work of Dennis et al^5-6on the use of heparin in the treatment of malaria. Many factors related to the role of the parasitized erythrocyte have been implicated in the pathogenesis of cerebral malaria, but the point we wanted to emphasize was that the alterations of the vascular permeability and the obstruction of the circulation occur<i>before</i>the plugging of the vessels by the RBCs, as clearly demonstrated by Maegraith.⁷We strongly believe that this early alteration of the vasculature is the result of the immune response of the host to the parasite and that this vasculopathy http://purl.org/coar/access_right/c_16ec

oai:impactu.colav.co:6a457e8e5418a51e32f7910d 2026-07-03T06:21:20Z

http://purl.org/coar/resource_type/c_0857 EN 1982-07-01 39 7 455 455 10.1001/archneur.1982.00510190073031 https://pubmed.ncbi.nlm.nih.gov/7103788 1538-3687 0003-9942 https://openalex.org/W5265710 Såenz Lope Enrique https://openalex.org/A5003424512 Tanarro F https://openalex.org/A5001364872 American Medical Association American Medical Association Epilepsy research and treatment Psychiatry and Mental health Medicine Health Sciences Clonazepam Epilepsy Reflex Epilepsy Psychology Reading (process) Audiology Anesthesia Psychiatry Philosophy Linguistics Pharmacological Effects and Toxicity Studies Genetics and Neurodevelopmental Disorders <h3>To the Editor.—</h3> Primary reading epilepsy (PRE) is a form of reflex epilepsy that is considered hereditary,¹and whose effective treatment in three cases with clonazepam^2-4and in one case with valproate sodium⁵has been described. We studied a man with PRE whose attacks were controlled with clonazepam. His 4-year-old son had myoclonic epilepsy that was controlled with valproate sodium. <h3>Report of a Case.—</h3> A 32-year-old man, first seen seven years earlier, had suffered three generalized convulsive seizures, while reading, since age 18 years. After these, and always when reading texts that required concentrated attention, he felt several throat spasms that reached tonic protrusion of the jaw, and that forced him to stop reading for fear of suffering a new generalized attack; this happens daily, aggravated by excitation or loss of sleep. He always pronounces words to himself in reading. The attacks occur sometimes during an excited http://purl.org/coar/access_right/c_16ec

oai:impactu.colav.co:6a457e8e5418a51e32f7910e 2026-07-04T12:35:04Z

http://purl.org/coar/resource_type/c_efa0 EN 2004-08-01 82 8 608 15 https://pubmed.ncbi.nlm.nih.gov/15375451 https://openalex.org/W2116135672 Gore Saravia Nancy https://orcid.org/0000-0002-2440-9658 https://openalex.org/A5002136191 Francisco Miranda Juan https://openalex.org/A5109086593 Global Health and Surgery Public Health, Environmental and Occupational Health Medicine Health Sciences Context (archaeology) Developing country Business Economic growth Knowledge economy Service (business) Investment (military) Sustainability Economics Marketing Political science Economy Ecology Politics Paleontology Law Biology Opportunity is the driving force of migration. Unsatisfied demands for higher education and skills, which have been created by the knowledge-based global economy, have generated unprecedented opportunities in knowledge-intensive service industries. These multi-trillion dollar industries include information, communication, finance, business, education and health. The leading industrialized nations are also the focal points of knowledge-intensive service industries and as such constitute centres of research and development activity that proactively draw in talented individuals worldwide through selective immigration policies, employment opportunities and targeted recruitment. Higher education is another major conduit of talent from less-developed countries to the centres of the knowledge-based global economy. Together career and educational opportunities drive "brain drain and recirculation". The departure of a large proportion of the most competent and innovative individuals from developing nations slows the achievement of the critical mass needed to generate the enabling context in which knowledge creation occurs. To favourably modify the asymmetric movement and distribution of global talent, developing countries must implement bold and creative strategies that are backed by national policies to: provide world-class educational opportunities, construct knowledge-based research and development industries, and sustainably finance the required investment for these strategies. Brazil, China and India have moved in this direction, offering world-class education in areas crucial to national development, such as biotechnology and information technology, paralleled by investments in research and development. As a result, only a small proportion of the most highly educated individuals migrate from these countries, and research and development opportunities employ national talent and even attract immigrants. http://purl.org/coar/access_right/c_abf2 https://www.ncbi.nlm.nih.gov/pmc/articles/2622935 application/pdf

oai:impactu.colav.co:6a457e8e5418a51e32f7910f 2026-07-03T06:21:20Z

http://purl.org/coar/resource_type/c_6501 EN 1952-03-01 65 3 355 355 10.1001/archderm.1952.01530220096012 https://pubmed.ncbi.nlm.nih.gov/14893962 0003-987X 1538-3652 https://openalex.org/W1985735461 Silva Manuel https://orcid.org/0000-0002-4470-2202 https://openalex.org/A5100385310 American Medical Association American Medical Association Fungal Infections and Studies Epidemiology Medicine Health Sciences Sporotrichosis Dermatology Plant Pathogens and Fungal Diseases Antifungal resistance and susceptibility Sporotrichosis is very common in Colombia. There are probably several thousand victims throughout the country. At the dermatologic clinic of the University of Colombia and in Acneform lesions, a type often seen in Colombia. private practice a patient is seen almost every week. The lesions are always on the skin and subcutaneous tissue. The diagnosis is easily made by culturing Sporotrichum schenckii in Sabouraud's medium. The causative organism of sporotrichosis lives in a saprophytic stage on vegetables and animals. It is found in vegetables used as food and many other plants in the woods, gardens, prairies, etc. One common method of contagion is through handling the straw used in packing fragile objects. In this instance the condition is an occupational disease. It is not unusual to see a series of patients who contracted the disease by handling contaminated straw from the same packing company. This method of transmission has undoubtedly http://purl.org/coar/access_right/c_16ec

oai:impactu.colav.co:6a457e8e5418a51e32f79110 2026-07-01T20:54:04Z

http://purl.org/coar/resource_type/c_6501 PT 2018-02-06 1 1 1 15 10.1000/riec.v1i1.1 https://openalex.org/W2805863727 Justamand Michel https://orcid.org/0000-0001-6944-5890 https://openalex.org/A5057581435 Funari Pedro Paulo A https://orcid.org/0000-0003-0183-7622 https://scholar.google.com/citations?user=gQgnsTgAAAAJ https://openalex.org/A5003294665 Alarcon Jimenez Andres https://scholar.google.com/citations?user=csR7ZM8AAAAJ https://openalex.org/A5004876117 Urban Development and Societal Issues Urban Studies Social Sciences Humanities Art Geography O presente artigo tem por objetivo relacionar, mesmo que brevemente, os conceitos de arqueologia, turismo e historia. Essa intencao tem por fim, ultimo, apontar as possibilidades do turismo no Parque Nacional Serra da Capivara – PNSC/PI, localizado no sudoeste do estado brasileiro do Piaui. O parque foi identificado como patrimonio da humanidade pela UNESCO, ainda em 1991, mas ainda tem gerado pouca atracao turistica, segundo a otica dos autores, se comparado a outras atracoes, com a mesma alcunha da instituicao no mundo. Em outras partes milhoes de turistas recorrem aos monumentos e ou parques listados, gerando divisas e amplificando saberes e conhecimentos sobre a historia mais antiga desses locais. Dessa forma, se valoriza e reconhece o passado de lugares, muitas vezes, esquecidos, alem de permitir reflexoes novas sobre os vestigios arqueologicos. Alguns que sao, tao ricamente, observaveis, em especial, no PNSC, para entre seus futuros usuarios. Dessa forma, introduzimos o texto com a historia da ciencia, temos por objetivo amplificar as reflexoes sobre essa tematica, tivemos como metodo o levantamento bibliografico e de campo, que um dos autores realiza no parque e em sua circunferencia, desde 1996. Assim, temos como resultados a apresentacao de imagens que podem contribuir para os/as futuros/as turistas se interessarem por conhecer mais sobre o parque. Concluimos com a importância da permanencia da existencia desse parque e de outros para o incremento de saberes e conhecimentos socioculturais, pedagogicos e politicos. http://purl.org/coar/access_right/c_16ec

oai:impactu.colav.co:6a457e8e5418a51e32f79111 2026-07-04T18:45:33Z

http://purl.org/coar/resource_type/c_6501 EN 2006-08-01 132 8 847 847 10.1001/archotol.132.8.847-b 1538-361X 0886-4470 https://openalex.org/W2070413055 Acin Martinez Sergio https://orcid.org/0000-0001-7335-2865 https://openalex.org/A5052598875 Lozano García https://openalex.org/A5044015021 Roop Dennis R https://orcid.org/0000-0001-5868-5880 https://openalex.org/A5071625723 Caulı́N Carlos https://orcid.org/0000-0002-5059-0016 https://openalex.org/A5071658477 American Medical Association American Medical Association Cancer Research and Treatments Biotechnology Biochemistry, Genetics and Molecular Biology Life Sciences Gain of function Allele Cancer Medicine Cancer research Internal medicine Genetics Biology Mutation Gene Cancer, Hypoxia, and Metabolism Cancer-related Molecular Pathways Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Otolaryngology–Head & Neck Surgery HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Otolaryngology–Head & Neck Surgery journal http://purl.org/coar/access_right/c_16ec

oai:impactu.colav.co:6a457e8e5418a51e32f79112 2026-07-03T06:21:20Z

http://purl.org/coar/resource_type/c_6501 EN 1994-01-01 112 1 54 54 10.1001/archopht.1994.01090130064018 https://pubmed.ncbi.nlm.nih.gov/8285893 1538-3601 0003-9950 https://openalex.org/W2076091766 Rodríguez Álvaro https://orcid.org/0000-0001-6505-8834 https://openalex.org/A5101443639 American Medical Association American Medical Association Retinal and Optic Conditions Ophthalmology Medicine Health Sciences Ciliary arteries Central retinal vein Central retinal vein occlusion Occlusion Posterior segment of eyeball Posterior pole Central retinal artery Surgery Retinal Anatomy Radiology Ophthalmic artery Macular edema Blood flow Retinal Diseases and Treatments Retinal and Macular Surgery Valid basis for performing this operation requires further investigation. http://purl.org/coar/access_right/c_16ec

oai:impactu.colav.co:6a457e8e5418a51e32f79113 2026-07-03T06:21:20Z

http://purl.org/coar/resource_type/c_6501 EN 2004-10-01 122 10 1441 1441 10.1001/archopht.122.10.1441 https://pubmed.ncbi.nlm.nih.gov/15477454 1538-3601 0003-9950 https://openalex.org/W2053167113 Alio Jorge L https://orcid.org/0000-0002-8082-1751 https://scholar.google.com/citations?user=mj5NT6QAAAAJ https://openalex.org/A5091654539 https://openalex.org/A5113597750 American Medical Association American Medical Association Retinal and Macular Surgery Radiology, Nuclear Medicine and Imaging Medicine Health Sciences Inlay Ophthalmology Optometry Dentistry Intraocular Surgery and Lenses Optical Coherence Tomography Applications Epithelial perilenticular opacity is a new and serious complication in patients with intracorneal inlay implantation for the correction of hyperopia. http://purl.org/coar/access_right/c_16ec

oai:impactu.colav.co:6a457e8e5418a51e32f79114 2026-07-03T06:21:20Z

http://purl.org/coar/resource_type/c_6501 EN 1983-11-01 143 11 2089 2089 10.1001/archinte.1983.00350110067018 https://pubmed.ncbi.nlm.nih.gov/6357130 0003-9926 1538-3679 https://openalex.org/W1964217389 Mejía Gonzálo https://orcid.org/0009-0009-5622-6694 https://openalex.org/A5107536598 American Medical Association American Medical Association Systemic Lupus Erythematosus Research Rheumatology Medicine Health Sciences Transplantation Internal medicine Liver Diseases and Immunity Hepatitis C virus research The activity of systemic lupus erythematosus (SLE) was investigated in 18 recipients of 20 renal transplants by retrospective analysis of their medical records and by screening the ten patients with more than one year follow-up. Eight grafts were lost, all because of rejection occurring within the first year. From the 12 patients with functioning transplants, one was lost to follow-up at seven years and another had not completed one year. The remaining ten patients were studied, and no evidence of lupus nephritis was found despite serologically active SLE in four cases. Their follow-up was 4.5 +/- 1.3 years. Our study provides the relatively scarce literature on renal transplantation in patients with SLE with a series of 18 recipients of 20 allografts, confirms that the recurrence of lupus nephritis in the allografts is very rare, as previously suggested, and discloses that graft and patient survivals are comparable with those of the general nondiabetic transplant population. http://purl.org/coar/access_right/c_16ec

oai:impactu.colav.co:6a457e8e5418a51e32f79115 2026-07-03T06:21:20Z

http://purl.org/coar/resource_type/c_6501 EN 1966-10-01 118 4 322 322 10.1001/archinte.1966.00290160022005 0003-9926 1538-3679 https://openalex.org/W4230964566 Klahr Saulo https://openalex.org/A5113559961 American Medical Association American Medical Association Muscle metabolism and nutrition Cell Biology Biochemistry, Genetics and Molecular Biology Life Sciences Creatinine Renal function Excretion Urea Blood urea nitrogen Endocrinology Internal medicine Kidney Chemistry Medicine Biochemistry Diet and metabolism studies Metabolism and Genetic Disorders BLOOD urea nitrogen (BUN), or plasma creatinine, or both, are commonly used in clinical practice as routine procedures for the evaluation of renal function. These simple tests are also useful in following impairments in renal function brought about by disease^. Not always clearly recognized is the fact that BUN or plasma creatinine levels are the result of the interplay of two independent factors: production or synthesis, and excretion. Excretion is accomplished almost exclusively via the kidneys. Production of urea will depend on the many factors which affect human nitrogen metabolism. Rates of production of creatinine are a function of muscle mass. In the steady state, the rate of excretion of metabolic end products, such as creatinine and urea, must equal the rate of production. Therefore, if changes in plasma creatinine or urea are to reflect changes in excretion or clearance alone, rates of production must also be constant. Under most http://purl.org/coar/access_right/c_16ec

oai:impactu.colav.co:6a457e8e5418a51e32f79116 2026-07-03T06:21:20Z

http://purl.org/coar/resource_type/c_6501 EN 1975-02-01 32 2 155 155 10.1001/archpsyc.1975.01760200019001 https://pubmed.ncbi.nlm.nih.gov/1115564 0003-990X 1538-3636 https://openalex.org/W2129904772 León Carlos https://openalex.org/A5103418977 Psychedelics and Drug Studies Clinical Psychology Psychology Social Sciences Possession (linguistics) Psychodynamics Persecution Latin Americans Socioeconomic status Psychological intervention Phenomenon Psychic Social psychology Psychiatry Psychotherapist Sociology Medicine Epistemology Population Demography Philosophy Alternative medicine Political science Politics Law Pathology Linguistics Religion, Spirituality, and Psychology Paranormal Experiences and Beliefs The belief in persecution or possession by evil sprits is still popular in Latin American countries. Observations were made on 12 Columbian families who were haunted by 'el duende' (a special kind of imp, goblin, or poltergeist) and other spirits. Interviews elicited a detailed account of events, a demographic and socioeconomic description ofthe families, exploration of the psyhosocial antecedents, and a psychiatric evaluation of individual members of the group regared as key persons. Possible psychodynamic mechanisms are involved in the production of the phenomenon and factors in the successful 'therapeutic'interventions of spiritualist rather than psychiatric or religious healers. The interaction of culture , folk belief, and the brain impaired by lesion or faulty learning appears as the important accountable dimension. http://purl.org/coar/access_right/c_16ec

oai:impactu.colav.co:6a457e8e5418a51e32f79117 2026-07-03T06:21:20Z

http://purl.org/coar/resource_type/c_6501 EN 1992-11-01 118 11 1198 1203 10.1001/archotol.1992.01880110066014 https://pubmed.ncbi.nlm.nih.gov/1384561 0886-4470 1538-361X https://openalex.org/W2059284872 Eavey Roland D https://openalex.org/A5037891681 Castro‐Beiras Alfonso https://orcid.org/0000-0001-7925-7834 https://openalex.org/A5112358612 Northrop Clarinda https://openalex.org/A5113631318 American Medical Association American Medical Association Ear Surgery and Otitis Media Otorhinolaryngology Medicine Health Sciences Granulation tissue Middle ear Cholesteatoma Gerbil Amniotic fluid Pathology Temporal bone Anatomy Inner ear Animal model Tympanosclerosis Surgery Biology Fetus Wound healing Pregnancy Genetics Ischemia Endocrinology Cardiology Reconstructive Facial Surgery Techniques Nasal Surgery and Airway Studies Human histopathologic studies have demonstrated that amniotic fluid cellular contents, keratinized squamous epithelial cells and lanugo hair, induce an intense inflammatory reaction including granulation tissue in the neonatal temporal bone. To investigate this reaction over a prolonged period, an animal model was studied. An aliquot of sterilized autologous hair and keratinized epithelial cells was placed into 14 gerbil bullae; saline was used as a contralateral control. The animals were sacrificed at intervals up to 6 months and the temporal bones were studied by light microscopy. All animals demonstrated nonpurulent inflammatory changes on the experimental side including granulation tissue, osteoneogenesis, tympanosclerosis, and cholesteatoma; the control side demonstrated minimal middle ear changes. We conclude that in this model autologous keratinized tissue provokes a foreign body response similar to the granulation tissue observed in human infants and, further, that over a prolonged period the middle ear demonstrates more severe pathologic consequences. http://purl.org/coar/access_right/c_16ec

oai:impactu.colav.co:6a457e8e5418a51e32f79118 2026-07-03T06:21:20Z

http://purl.org/coar/resource_type/c_6501 EN 1974-03-01 127 3 379 379 10.1001/archpedi.1974.02110220077011 https://pubmed.ncbi.nlm.nih.gov/4592549 0002-922X 2374-3018 https://openalex.org/W2073174832 Garcı́A De Olarte Diana https://openalex.org/A5066404730 Viral gastroenteritis research and epidemiology Infectious Diseases Medicine Health Sciences Ampicillin Diarrhea Placebo Shigellosis Internal medicine Adverse effect Gastroenterology Antibiotics Enteropathogenic Escherichia coli Shigella Dysentery Salmonella Microbiology Escherichia coli Biology Pathology Alternative medicine Genetics Bacteria Biochemistry Gene Child Nutrition and Water Access Infant Nutrition and Health Rectal swabs and stool specimens for culture were collected from 2,236 infants and children hospitalized for severe diarrhea in Medellin, Colombia, during a two-year period. Salmonellae were identified in 280, enteropathogenic<i>Escherichia coli</i>in 117, and shigellae in 61 specimens. One hundred eighty-six patients with enteropathogens and 96 with acute diarrhea of unknown cause were assigned randomly to ampicillin or placebo treatment given parenterally or orally for five days. No adverse or beneficial effect of ampicillin was found in infants with enteropathogenic<i>E coli</i>or with diarrhea of unknown cause. For<i>Salmonella</i>infection, orally given ampicillin was equivalent to placebo therapy; however, there was 100% bacteriologic cure without short-term relapse in those given ampicillin intramuscularly. This was a statistically significant difference from placebo or orally given ampicillin treatment. Ampicillin therapy for shigellosis substantially shortened the period of diarrhea, fever and, positive stool cultures compared with placebo treatment. http://purl.org/coar/access_right/c_16ec

oai:impactu.colav.co:6a457e8e5418a51e32f79119 2026-07-03T06:21:20Z

http://purl.org/coar/resource_type/c_efa0 EN 1997-04-01 133 4 451 454 10.1001/archderm.133.4.451 0003-987X 1538-3652 https://openalex.org/W4255111381 Acosta A https://openalex.org/A5055172716 American Medical Association American Medical Association Nonmelanoma Skin Cancer Studies Epidemiology Medicine Health Sciences Surgery Cancer surgery Reconstructive surgery Cancer Anesthesia General surgery Internal medicine Dermatologic Treatments and Research Body Contouring and Surgery Objective: To describe and define the viability of using tumescent anesthetic technique (TAT) in skin cancer reconstructive surgery with good results and without adverse reactions. Design: Phase 3 clinical trial. Setting: The National Institute of Cancer in Bogotá, Colombia, is a national referral center with an institutional practice. Patients: From June 1992 to June 1994, 86 ambulant patients, who were of low to middle socioeconomic class, were referred from oncology to dermatology for moderately complicated surgery. As outpatients, they http://purl.org/coar/access_right/c_16ec

oai:impactu.colav.co:6a457e8e5418a51e32f7911a 2026-07-03T06:21:20Z

http://purl.org/coar/resource_type/c_6501 EN 1971-10-01 122 4 325 325 10.1001/archpedi.1971.02110040109009 https://pubmed.ncbi.nlm.nih.gov/5115529 1072-4710 1538-3628 https://openalex.org/W2075271677 Lynch Peter https://openalex.org/A5114253301 American Medical Association American Medical Association Fungal Infections and Studies Epidemiology Medicine Health Sciences Sporotrichosis Psychology Dermatology Plant Pathogens and Fungal Diseases Plant Pathogenic Bacteria Studies Although sporotrichosis is reputed to occur only rarely in children, we have seen 11 such children in the last ten years. Questionnaires were sent to the parents of these children and the data from the questionnaires were compared to the data available for 36 previously reported cases in children. We found that the clinical lesions of sporotrichosis are identical in children and adults but that children are a little less likely to have visible lymphatic satellite lesions and are a little more likely to have lesions on the face and trunk, probably as a result of rough and tumble outdoor play. Oral potassium iodide therapy was curative and recurrences were not a problem. Scarring occurred at the site of the original lesion but was not considered disfiguring. http://purl.org/coar/access_right/c_16ec

oai:impactu.colav.co:6a457e8e5418a51e32f7911b 2026-07-03T06:21:20Z

http://purl.org/coar/resource_type/c_6501 EN 1984-03-01 41 3 294 294 10.1001/archneur.1984.04050150072020 https://pubmed.ncbi.nlm.nih.gov/6696648 1538-3687 0003-9942 https://openalex.org/W2016192465 Vela‐Bueno Antonio https://openalex.org/A5112739127 American Medical Association American Medical Association Genetic Syndromes and Imprinting Genetics Biochemistry, Genetics and Molecular Biology Life Sciences Sleep (system call) Psychology Medicine Neuroscience Computer science Operating system Child Nutrition and Feeding Issues Family and Disability Support Research Nine patients with the Prader-Willi syndrome, ranging in age from 3 to 21 years, were examined clinically as well as studied in the sleep laboratory. They had striking disturbances of sleep-wakefulness patterns. All patients except one had the symptom of excessive daytime sleepiness. The most striking finding was the presence in five patients of rapid-eye-movement (REM) sleep occurring at sleep onset (SOREM). None of the patients had the condition of sleep apnea. One patient, however, demonstrated severe hypoventilation during REM sleep; the lowest value recorded for O2 saturation was 40%, with a consistent value below 50% for as long as ten to 15 minutes. Previous findings have indicated that the Prader-Willi syndrome is of hypothalamic origin. We hypothesize that both the SOREM and O2 desaturation findings in our patients with the Prader-Willi syndrome are also a result of hypothalamic changes. http://purl.org/coar/access_right/c_16ec

oai:impactu.colav.co:6a457e8e5418a51e32f7911c 2026-07-04T12:24:11Z

http://purl.org/coar/resource_type/c_efa0 IT 2008-06-01 25 3 184 8 https://pubmed.ncbi.nlm.nih.gov/18580995 https://openalex.org/W1994047959 Cuervo Sonia I https://openalex.org/A5060352526 Cortés Luna Jorge Alberto https://orcid.org/0000-0002-8636-1071 55176475800 https://openalex.org/A5015101485 https://openalex.org/A5051464519 https://openalex.org/A5054209997 https://openalex.org/A5075469836 https://openalex.org/A5103989511 https://openalex.org/A5104322974 https://openalex.org/A5113785194 https://scholar.google.com/citations?user=a2wZuTcAAAAJ https://scholar.google.com/citations?user=cFp-cZ4AAAAJ Rodríguez Acevedo Elizabeth Cristina https://orcid.org/0000-0003-2969-5611 https://openalex.org/A5001936982 https://openalex.org/A5038207776 https://openalex.org/A5076325154 https://scholar.google.com/citations?user=1BzZcBMAAAAJ https://scholar.google.com/citations?user=suN1iyYAAAAJ Natan Hormaza https://openalex.org/A5050556673 Vargas Erwing https://openalex.org/A5082892071 Neutropenia and Cancer Infections Oncology Medicine Health Sciences Bacteremia Leuconostoc Meningitis Peritonitis Alimentary tract Urinary system Intensive care medicine Microbiology Cancer Internal medicine Pediatrics Biology Bacteria Lactic acid Antibiotics Genetics Bacterial Identification and Susceptibility Testing Infections and bacterial resistance The species of Leuconostoc are uncommon opportunistic pathogens, which can be isolated in critically ill patients, immunocompromised hosts and in nosocomial infections. They are mostly isolated in bacteremia associated to intravascular devices and to the use of total parenteral nutrition. Nevertheless, other infections due to Leuconostoc sp have been described among which, meningitis, bloodstream infections, urinary tract infections and peritonitis have been reported. In this article we describe a series of cancer patients with Leuconostoc sp infections and their associated clinical conditions, and a literature review is presented. http://purl.org/coar/access_right/c_16ec

oai:impactu.colav.co:6a457e8e5418a51e32f7911d 2026-07-03T06:21:20Z

http://purl.org/coar/resource_type/c_6501 EN 1991-06-01 127 6 888 889 10.1001/archderm.127.6.888 https://pubmed.ncbi.nlm.nih.gov/2036039 0003-987X 1538-3652 https://openalex.org/W2064334387 Mosquera Jaramillo Fernando https://orcid.org/0000-0001-7550-1895 https://openalex.org/A5017969895 American Medical Association American Medical Association Tumors and Oncological Cases Pathology and Forensic Medicine Medicine Health Sciences Girl Dermatology Pathology Psychology Developmental psychology Oral Health Pathology and Treatment Cancer and Skin Lesions REPORT OF A CASE A 12-year-old Indian girl, from Puerto Inírida in the comissary of Guainía in the Colombian Orinochian jungle in South America, presented for evaluation of asymptomatic oral lesions of approximately 1 year's duration; the lesions were initially noted on the mucosa of the lips, but they progressively extended to other areas of the oral mucosa. The girl was otherwise in good health, and her medical history was essentially normal. According to her relatives, many members of their tribe, especially children, had similar http://purl.org/coar/access_right/c_16ec

oai:impactu.colav.co:6a457e8e5418a51e32f7911e 2026-07-03T06:21:20Z

http://purl.org/coar/resource_type/c_6501 EN 1979-05-01 36 5 266 266 10.1001/archneur.1979.00500410044005 https://pubmed.ncbi.nlm.nih.gov/375881 1538-3687 0003-9942 https://openalex.org/W1989985027 Roelofs Robert https://openalex.org/A5053169928 American Medical Association American Medical Association Muscle Physiology and Disorders Molecular Biology Biochemistry, Genetics and Molecular Biology Life Sciences Duchenne muscular dystrophy Penicillamine Medicine Placebo Clinical trial Analysis of variance Muscular dystrophy Pyridoxine Muscle tone Internal medicine Physical therapy Physical medicine and rehabilitation Alternative medicine Pathology Genetic Neurodegenerative Diseases Biotin and Related Studies Eleven boys with Duchenne's muscular dystrophy, randomly assigned to placebo (group A, n = 6) or penicillamine treatment (group B, n = 5), received three capsules per day containing lactose or 250 mg of penicillamine. All patients received pyridoxine, 50 mg daily. Mean age at entrance into study was similar for both groups (group A , 86.7 +/- 31.6 months; group B, 95.4 +/- 43.4 months). Clinical status was assessed with timed functional activities, manometric measurements of muscle force, and manual muscle testing. After 14 to 16 months of treatment, statistical analysis (analysis of variance) of data disclosed no significant differences in the overall performance of the two groups. A longer-duration trial, involving younger patients, is needed to determine whether there are palliative effects of penicillamine or other potentially therapeutic agents. http://purl.org/coar/access_right/c_16ec

oai:impactu.colav.co:6a457e8e5418a51e32f7911f 2026-07-03T06:21:20Z

http://purl.org/coar/resource_type/c_6501 EN 1981-05-01 99 5 832 836 10.1001/archopht.1981.03930010832008 https://pubmed.ncbi.nlm.nih.gov/7236085 1538-3601 0003-9950 https://openalex.org/W1975692848 Heijl Anders https://orcid.org/0000-0001-7233-6919 https://scholar.google.com/citations?user=uSJtbb4AAAAJ https://openalex.org/A5022617905 Drance S M https://openalex.org/A5113647624 American Medical Association American Medical Association Glaucoma and retinal disorders Ophthalmology Medicine Health Sciences Glaucoma Visual field Perimeter octopus (software) Optometry Computer science Artificial intelligence Mathematics Geometry Quantum mechanics Physics Retinal Imaging and Analysis Corneal surgery and disorders The ability to detect glaucomatous field defects of three automatic computerized perimeters (COMPETER, OCTOPUS, and PERIMETRON) was compared in a clinical study of 74 patients. This study included patients with glaucoma, those with suspected glaucoma in whom the visual fields were completely normal, and normal subjects. The reference fields were obtained by careful static and kinetic manual perimetry on the Tübinger perimeter. All the automatic instruments gave similar high rates of detection of visual field loss and low false-positive test results. Quantity conventional manual perimetry is necessary to support automatic perimetric results, but automatic perimeters already can do a large proportion of routine perimetric screening. http://purl.org/coar/access_right/c_16ec

oai:impactu.colav.co:6a457e8f5418a51e32f79120 2026-07-03T06:21:20Z

http://purl.org/coar/resource_type/c_6501 EN 1998-06-01 55 6 857 857 10.1001/archneur.55.6.857 https://pubmed.ncbi.nlm.nih.gov/9626779 1538-3687 0003-9942 https://openalex.org/W2143680625 Natelson Benjamin H https://scholar.google.com/citations?user=NCsgozYAAAAJ https://openalex.org/A5113544028 Suarez Ronald https://openalex.org/A5016062597 Terrence Christopher F https://openalex.org/A5008193735 Turizo Rosa https://openalex.org/A5042145820 American Medical Association American Medical Association Cardiac electrophysiology and arrhythmias Cardiology and Cardiovascular Medicine Medicine Health Sciences Epilepsy Endocardium Cardiomyopathy Cardiology Disease Heart disease Internal medicine Pathology Heart failure Psychiatry Takotsubo Cardiomyopathy and Associated Phenomena Cardiovascular Syncope and Autonomic Disorders Our results support the hypothesis that patients with epilepsy who die suddenly and unexpectedly have cardiac pathologic conditions that may be responsible for their deaths. http://purl.org/coar/access_right/c_16ec

oai:impactu.colav.co:6a457e8f5418a51e32f79121 2026-07-03T06:21:20Z

http://purl.org/coar/resource_type/c_6501 EN 1998-03-01 116 3 286 286 10.1001/archopht.116.3.286 https://pubmed.ncbi.nlm.nih.gov/9514480 1538-3601 0003-9950 https://openalex.org/W2135382592 Scott Ingrid U https://orcid.org/0000-0002-3908-7153 https://openalex.org/A5077460225 American Medical Association American Medical Association Glaucoma and retinal disorders Ophthalmology Medicine Health Sciences Trabeculectomy Surgery Intraocular pressure Endophthalmitis Mitomycin C Glaucoma Proteoglycans and glycosaminoglycans research Retinal Diseases and Treatments Primary trabeculectomy with the use of intraoperative mitomycin lowered the IOP by 30% or more in 78% (at 2 years) to 86% (at 1 year) of the cases and is associated with a marked reduction in the percentage of patients who require glaucoma medication. Success rates must be evaluated in light of such risks as endophthalmitis and hypotony. http://purl.org/coar/access_right/c_16ec

oai:impactu.colav.co:6a457e8f5418a51e32f79122 2026-07-01T20:54:04Z

http://purl.org/coar/resource_type/c_6501 PT 2021-03-01 10.0000/hoplos.v4i6.42795 2340-4078 0300-5267 https://openalex.org/W3108065905 De Morais Lima Rafael https://orcid.org/0000-0003-4656-8980 https://openalex.org/A5057080623 Soares Salgado Felipe Augusto https://openalex.org/A5077068553 Marreiro Matheus Moraes Alves https://orcid.org/0000-0002-4508-5285 https://scholar.google.com/citations?user=c9XqigUAAAAJ https://openalex.org/A5077369805 Sociedad Hispano-Luso-Americana de Lepidopterología Sociedad Hispano-Luso-Americana de Lepidopterología Global Security and Public Health Sociology and Political Science Social Sciences Framing (construction) Political science Computer security Computer science Engineering Structural engineering Terrorism, Counterterrorism, and Political Violence Political Conflict and Governance O presente trabalho teve como intuito aplicar o Security Framing para analisar o caso do ecoterrorismo nos Estados Unidos da América. Em 2002, um documento oficial do FBI apontava o ecoterrorismo como a ameaça doméstica número 1 dos EUA. Observou-se, então, um movimento de lobby para tipificar os atos de movimentos ambientais extremistas como ações de terrorismo, contribuindo para o deslocamento do objeto fim da agenda de segurança do FBI - do indivíduo para o capital. A análise elaborada, portanto, construiu um quadro de trabalho e analisou o Framing de ressonância da narrativa do capital (lobby) sobre o governo norte-americano. Percebeu-se que a narrativa do capital encontrou eco nas crenças e valores da audiência, atestando a credibilidade do autor do discurso e a saliência do tema na audiência. http://purl.org/coar/access_right/c_abf2 https://doaj.org/article/59d9c4be6cbf403db4298aa039bec14f application/pdf

oai:impactu.colav.co:6a457e8f5418a51e32f79123 2026-07-03T06:21:20Z

http://purl.org/coar/resource_type/c_efa0 EN 2002-07-01 4 3 157 163 10.1001/archfaci.4.3.157 https://pubmed.ncbi.nlm.nih.gov/12167073 1521-2491 1538-3660 https://openalex.org/W2171114812 Pedroza Fernando https://openalex.org/A5067202194 Nasal Surgery and Airway Studies Surgery Medicine Health Sciences Rhinoplasty Nose Nasal cartilages Nasal bone Rotation (mathematics) Orthodontics Computer vision Computer science Sinusitis and nasal conditions The new domes technique is a conservative, predictable, and stable technique especially applicable for patients with drooped and wide nasal tips to achieve a more projected, rotated, narrowed, and natural appearance. http://purl.org/coar/access_right/c_16ec

oai:impactu.colav.co:6a457e8f5418a51e32f79124 2026-07-03T06:21:20Z

http://purl.org/coar/resource_type/c_6501 EN 1993-03-01 111 3 365 365 10.1001/archopht.1993.01090030083044 https://pubmed.ncbi.nlm.nih.gov/8447748 1538-3601 0003-9950 https://openalex.org/W1996642114 Luz Araujo Martha https://openalex.org/A5111606765 American Medical Association American Medical Association Glaucoma and retinal disorders Ophthalmology Medicine Health Sciences Baseline (sea) Visual field Optometry Audiology Computer science Biology Fishery Visual perception and processing mechanisms Retinal Imaging and Analysis Each examination method identified pointwise changes not detected by the other, the combined effect of false-positive errors (imperfect specificity) and false-negative errors (imperfect sensitivity) with each of the two methods. The findings relating to clusters could represent a better sensitivity of the full-threshold method in detecting visual field deterioration, a better specificity of the suprathreshold method, or both. http://purl.org/coar/access_right/c_16ec

oai:impactu.colav.co:6a457e8f5418a51e32f79125 2026-07-03T06:21:20Z

http://purl.org/coar/resource_type/c_6501 ES 1997-05-01 115 5 670 670 10.1001/archopht.1997.01100150672022 https://pubmed.ncbi.nlm.nih.gov/9152139 1538-3601 0003-9950 https://openalex.org/W2081371652 Wong Vernon K https://openalex.org/A5109194159 American Medical Association American Medical Association Ocular Infections and Treatments Ophthalmology Medicine Health Sciences Candida parapsilosis Pars plana Vitrectomy Fluconazole Endophthalmitis Amphotericin B Candida albicans Surgery Antifungal Visual acuity Dermatology Biology Microbiology Glaucoma and retinal disorders Ocular Diseases and Behçet’s Syndrome We describe a patient with bilateral, delayed endophthalmitis who underwent bilateral pars plana vitrectomy, total capsulectomy, intraocular lens exchange, intravitreal injection of amphotericin B, and oral fluconazole therapy. The long-term inflammation resolved, and vitreous cultures from both eyes yielded Candida parapsilosis. Histopathologic examination revealed sequestered yeast forms in the capsular bags. http://purl.org/coar/access_right/c_16ec

oai:impactu.colav.co:6a457e8f5418a51e32f79126 2026-07-03T06:21:20Z

http://purl.org/coar/resource_type/c_6501 EN 1991-06-01 127 6 891 891 10.1001/archderm.1991.01680050135018 0003-987X 1538-3652 https://openalex.org/W2027730303 Jaramillo Ayerbe Felipe https://orcid.org/0000-0002-0982-4335 https://openalex.org/A5033147211 American Medical Association American Medical Association Oral and Maxillofacial Pathology Oral Surgery Dentistry Health Sciences Girl Medicine Tongue Oral mucosa Asymptomatic Dermatology Pathology Psychology Developmental psychology Oral and Craniofacial Lesions Tumors and Oncological Cases <h3>REPORT OF A CASE</h3> A 12-year-old Indian girl, from Puerto Inírida in the comissary of Guainía in the Colombian Orinochian jungle in South America, presented for evaluation of asymptomatic oral lesions of approximately 1 year's duration; the lesions were initially noted on the mucosa of the lips, but they progressively extended to other areas of the oral mucosa. The girl was otherwise in good health, and her medical history was essentially normal. According to her relatives, many members of their tribe, especially children, had similar ailments, some with lesions even more prominent. Findings from the physical examination revealed numerous irregularly distributed, sharply circumscribed, rounded or ovoid firm papules with a slightly corrugated surface. These lesions were 1 to 5 mm in diameter (Fig 1) and were located on the mucosa of lips, cheeks, tongue, and hard palate. The color of most of the lesions was similar to that of the http://purl.org/coar/access_right/c_16ec

oai:impactu.colav.co:6a457e8f5418a51e32f79127 2026-07-04T13:12:18Z

http://purl.org/coar/resource_type/c_0857 EN 2007-12-01 143 12 1600 2 10.1001/archderm.143.12.1600 https://pubmed.ncbi.nlm.nih.gov/18087026 0003-987X 1538-3652 https://openalex.org/W2078201467 Motta Beltrán Adriana https://orcid.org/0000-0002-1924-1256 https://openalex.org/A5027440123 Zerrweck López Carlos https://openalex.org/A5110287264 Acosta Álvaro https://openalex.org/A5101070525 Peñaranda Camilo https://openalex.org/A5033573588 Acosta Losada Orlando https://orcid.org/0000-0002-1267-098X https://openalex.org/A5077783459 https://openalex.org/A5084882443 https://openalex.org/A5102151401 https://scholar.google.com/citations?user=2b-NxK8AAAAJ López Carlos American Medical Association American Medical Association Nail Diseases and Treatments Epidemiology Medicine Health Sciences Otorhinolaryngology Family medicine Neurology General surgery Psychiatry Nonmelanoma Skin Cancer Studies Cutaneous lymphoproliferative disorders research Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Dermatology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Dermatology journal http://purl.org/coar/access_right/c_16ec

oai:impactu.colav.co:6a457e8f5418a51e32f79128 2026-07-04T19:17:46Z

http://purl.org/coar/resource_type/c_0857 EN 1999-02-01 135 2 217 217 10.1001/archderm.135.2.217 https://pubmed.ncbi.nlm.nih.gov/10052422 0003-987X 1538-3652 https://openalex.org/W1971201727 Sanclemente Mesa Gloria https://orcid.org/0000-0002-1555-2751 https://openalex.org/A5023620667 Falabella Rafael https://openalex.org/A5036793477 Escobar Carlos E. Arroyave Jose A. American Medical Association American Medical Association Skin and Cellular Biology Research Cell Biology Biochemistry, Genetics and Molecular Biology Life Sciences Medicine Dermatology Ichthyosis Siemens Epidermolysis bullosa Quantum mechanics Physics Ichthyosis bullosa Siemens ammonia lactate epidermolytic hyperkeratosis Autoimmune Bullous Skin Diseases Plant Reproductive Biology In 283 patients with port-wine stains attending a laser clinic, we studied the family history of birthmarks. 2 We were surprised to find that 72 patients (25.4%) had a family history of birthmarks, and 42 (15%) had a family history of vascular birthmarks; 20 of those were strawberry hemangiomas and 22 (7%) were port-wine stains. The figures for port-wine stains are higher than expected from the prevalence in the population, and our patients, like those in the study by Blei et al, 1 had vascular malformations and hemangiomas present in http://purl.org/coar/access_right/c_16ec

oai:impactu.colav.co:6a457e8f5418a51e32f79129 2026-07-03T06:21:20Z

http://purl.org/coar/resource_type/c_6501 HT 1978-05-01 35 5 271 271 10.1001/archneur.1978.00500290017004 https://pubmed.ncbi.nlm.nih.gov/348169 1538-3687 0003-9942 https://openalex.org/W2071559627 Toro Gabriel https://openalex.org/A5110069664 American Medical Association American Medical Association Malaria Research and Control Public Health, Environmental and Occupational Health Medicine Health Sciences Cerebral Malaria Malaria Dexamethasone Pathology Plasmodium falciparum Granuloma Gliosis Internal medicine Mosquito-borne diseases and control Infectious Encephalopathies and Encephalitis Neuropathologic examination of 19 fatal cases of cerebral malaria and a review of the literature showed that the epidemiologic, clinical, and pathologic features of this entity suggest consideration of cerebral malaria as a form of disseminated vasculomyelinopathy, a hyperegic reaction of the CNS to the antigenic challenge of Plasmodium falciparum infection. Experimental evidence also substantiates this view The initial event seems to be vasculopathy, with alteration of the endothelial permeability, followed by brain edema, perivascular infiltrates and ring hemorrhages, perivascular demyelination, and gliosis (malarial granuloma) in the late stages. This chain of events could be interrupted early in its course by corticosteroids. Parenteral dexamethasone should then be seriously considered at the first signs of involvement of the CNS during P falciparum malaria along with the standard forms of antimalarial therapy. http://purl.org/coar/access_right/c_16ec

oai:impactu.colav.co:6a457e8f5418a51e32f7912a 2026-07-04T13:17:56Z

http://purl.org/coar/resource_type/c_6501 EN 2011-08-01 68 8 838 838 10.1001/archgenpsychiatry.2011.77 https://pubmed.ncbi.nlm.nih.gov/21810647 0003-990X 1538-3636 https://openalex.org/W2110436575 Scott Kate Margaret https://orcid.org/0000-0002-3928-8377 https://scholar.google.com/citations?user=kgc_8uMAAAAJ https://openalex.org/A5011205980 Posada Villa Jose Abelardo 6504271350 Child and Adolescent Psychosocial and Emotional Development Clinical Psychology Psychology Social Sciences Anxiety Psychosocial Mental health Context (archaeology) Population Age of onset Psychiatry Depression (economics) Hazard ratio Medicine Comorbidity Clinical psychology Disease Internal medicine Confidence interval Environmental health Macroeconomics Economics Biology Paleontology Child Abuse and Trauma Health, psychology, and well-being These results are consistent with the hypothesis that childhood adversities and early-onset mental disorders have independent, broad-spectrum effects that increase the risk of diverse chronic physical conditions in later life. They require confirmation in a prospectively designed study. The long course of these associations has theoretical and research implications. http://purl.org/coar/access_right/c_abf2 https://jamanetwork.com/journals/jamapsychiatry/articlepdf/1107420/yoa15022_838_844.pdf application/pdf

oai:impactu.colav.co:6a457e8f5418a51e32f7912b 2026-07-03T06:21:20Z

http://purl.org/coar/resource_type/c_6501 EN 1971-12-01 104 6 592 592 10.1001/archderm.1971.04000240016002 0003-987X 1538-3652 https://openalex.org/W4231367674 Falabella Rafael https://openalex.org/A5036793477 American Medical Association American Medical Association melanin and skin pigmentation Cell Biology Biochemistry, Genetics and Molecular Biology Life Sciences Medicine Epidermis (zoology) Suction blister Dermatology Etiology Grafting Skin grafting Pathology Surgery Anatomy Organic chemistry Chemistry Polymer Reconstructive Facial Surgery Techniques Corneal Surgery and Treatments Achromic lesions are numerous and their significance is especially great in areas of the world with large numbers of dark-skinned individuals. Therapy has been difficult and discouraging. In a new surgical technique, isolated epidermis obtained by suction at 200 mm Hg is successfully used as a pigment-bearing graft to cover either achromic defects or granulating areas resulting from skin damage of diverse etiology. The procedure was useful in four typical cases. http://purl.org/coar/access_right/c_16ec

oai:impactu.colav.co:6a457e8f5418a51e32f7912c 2026-07-03T06:21:20Z

http://purl.org/coar/resource_type/c_6501 EN 1986-04-01 122 4 413 413 10.1001/archderm.1986.01660160069021 https://pubmed.ncbi.nlm.nih.gov/3006602 0003-987X 1538-3652 https://openalex.org/W2032625286 Restrepo Moreno Angela https://openalex.org/A5108073284 American Medical Association American Medical Association Fungal Infections and Studies Epidemiology Medicine Health Sciences Sporotrichosis Itraconazole Dermatology Azole Terbinafine Discontinuation Surgery Pharmacotherapy Mycosis Antifungal Internal medicine Antifungal resistance and susceptibility Plant Pathogens and Fungal Diseases Itraconazole, a new orally absorbable azole derivative, was used for the treatment of 17 patients with cutaneous and lymphangitic sporotrichosis. The drug, administered at a dose of 100 mg/day, proved to be effective in all cases. Lesions disappeared and cultures became negative after 90 to 180 days of therapy. There were no major side effects. Posttherapy evaluations, done in 14 of 17 cases for an average of 115 days, revealed no relapses. Objective evaluation of the treatment by means of a scoring system indicated complete resolution of the pretherapy abnormalities at varying periods; thus, 35.3% (six of 17) of the patients had recovered by 90 days, 45.4% (five of 11) by 120 days, and 83.3% (five of six) by 150 days of therapy. Consequently, therapy with itraconazole is an adequate alternative to iodide treatment in sporotrichosis. http://purl.org/coar/access_right/c_16ec

oai:impactu.colav.co:6a457e8f5418a51e32f7912d 2026-07-03T06:21:20Z

http://purl.org/coar/resource_type/c_6501 EN 1970-08-01 126 2 272 272 10.1001/archinte.1970.00310080078010 https://pubmed.ncbi.nlm.nih.gov/4914780 0003-9926 1538-3679 https://openalex.org/W1985371092 Yunis Adel A https://openalex.org/A5111598456 American Medical Association American Medical Association Metabolism and Genetic Disorders Clinical Biochemistry Biochemistry, Genetics and Molecular Biology Life Sciences Chloramphenicol Bone marrow Medicine Internal medicine Biology Microbiology Antibiotics Mitochondrial Function and Pathology Amino Acid Enzymes and Metabolism Chloramphenicol is a potent inhibitor of mitochondrial protein synthesis. Recent studies on rabbit and human bone marrow mitochondria strongly suggest a relationship between inhibition of protein synthesis and myelotoxicity from chloramphenicol. A thorough electron microscopic study of bone marrow mitochondria derived from patients receiving chloramphenicol indicates that this drug induces ultrastructural modifications resulting in an increase in the density of the mitochondrial matrix. Excellent correlation is observed between the extent of the ultrastructural changes and serum levels of free chloramphenicol. The results lend further support to the hypothesis that reversible bone marrow suppression from chloramphenicol results from inhibition by the drug of mitochondrial protein synthesis. http://purl.org/coar/access_right/c_16ec

oai:impactu.colav.co:6a457e8f5418a51e32f7912e 2026-07-01T20:54:04Z

http://purl.org/coar/resource_type/c_0857 ET 1979-07-01 36 7 453 454 10.1001/archneur.1979.00500430083022 https://pubmed.ncbi.nlm.nih.gov/454256 1538-3687 0003-9942 https://openalex.org/W1504456393 Toro G. Román Gustavo https://orcid.org/0000-0002-5429-445X https://openalex.org/A5102930901 Román Lydia https://openalex.org/A5108602335 American Medical Association American Medical Association Virology and Viral Diseases Epidemiology Medicine Health Sciences Subacute sclerosing panencephalitis Virology Pathology Measles Measles virus Vaccination Syphilis Diagnosis and Treatment To the Editor.— The review article by Risk et al ( Arch Neurol 35:494-502, 1978) seems to have overlooked substantial data regarding subacute sclerosing panencephalitis (SSPE) as it occurs in several Latin American countries. It is likely that they are unfamiliar with, or have no access to, the Latin American medical literature. In fact, we 1 have recently emphasized the high incidence of SSPE in South America based on the series from Sao Paulo, Brazil, 2 and the large number of cases from Colombia. 3 At the Fourth Pan-American Congress of Neurology, 4 a total of 110 cases of SSPE were collected from the joint Venezuelan, Peruvian, Mexican, and Colombian series. To our knowledge, this entity was first recognized in Colombia in 1966 by one of us (G.T.), and shortly thereafter, other cases were diagnosed in different areas of the country. A group of 22 patients was reported in 1970 to http://purl.org/coar/access_right/c_16ec

oai:impactu.colav.co:6a457e8f5418a51e32f7912f 2026-07-03T06:21:20Z

http://purl.org/coar/resource_type/c_6501 EN 1969-08-01 21 2 157 157 10.1001/archneur.1969.00480140057006 https://pubmed.ncbi.nlm.nih.gov/5792841 1538-3687 0003-9942 https://openalex.org/W2029682743 Stevens Janice R https://orcid.org/0009-0004-3786-650X https://openalex.org/A5103613988 American Medical Association American Medical Association Neural dynamics and brain function Cognitive Neuroscience Neuroscience Life Sciences Stimulation Deep brain stimulation Computer science Medicine Psychology Internal medicine Parkinson's disease Disease Neural and Behavioral Psychology Studies EEG and Brain-Computer Interfaces THE BEHAVIORAL effects of electrical stimulation in the deep structures of the temporal lobe in animals and man have been detailed by many investigators. 1-12 Due to the operative procedure in progress, most studies in man have been concerned with immediate behavioral and subjective effects. More recent investigations, employing chronic implanted electrodes for stimulation and recording, also deal primarily with the consequences of stimulation during and after the few seconds or minutes during which the current is applied. 13,14 The use of chronic implanted electrodes over extended periods permits a search for correlation of spontaneous or electrically induced abnormalities in electroencephalogram with behavior and subjective state under relatively natural conditions. Although recording from chronic indwelling cerebral electrodes from normal individuals has not been reported, records from nonepileptic subjects with mental retardation, intractable pain, and psychiatric disorders suggest that the cortex and subcortical nuclei of the temporal lobe normally present a http://purl.org/coar/access_right/c_16ec

oai:impactu.colav.co:6a457e8f5418a51e32f79130 2026-07-03T06:21:20Z

http://purl.org/coar/resource_type/c_6501 EN 1996-05-01 53 5 409 409 10.1001/archpsyc.1996.01830050045007 https://pubmed.ncbi.nlm.nih.gov/8624184 0003-990X 1538-3636 https://openalex.org/W2069202436 Silverman Kenneth https://orcid.org/0000-0003-2724-1413 https://openalex.org/A5085729704 Substance Abuse Treatment and Outcomes Epidemiology Medicine Health Sciences Abstinence Voucher Methadone Contingency management Randomized controlled trial Methadone maintenance Cocaine dependence Urine Psychiatry Psychology Anesthesia Addiction Internal medicine Intervention (counseling) Business Accounting Neurotransmitter Receptor Influence on Behavior Cannabis and Cannabinoid Research Voucher-based reinforcement contingencies can produce sustained cocaine abstinence in injecting polydrug abusers. http://purl.org/coar/access_right/c_16ec

oai:impactu.colav.co:6a457e8f5418a51e32f79131 2026-07-01T20:54:04Z

http://purl.org/coar/resource_type/c_6501 EN 1985-11-01 42 11 1034 1035 10.1001/archneur.1985.04060100012003 1538-3687 0003-9942 https://openalex.org/W2045215175 Calandre L https://openalex.org/A5012198784 Ortega Juan F https://orcid.org/0000-0003-3884-923X https://scholar.google.com/citations?user=yclzzgkAAAAJ https://openalex.org/A5029889488 Gomora S https://openalex.org/A5097201593 Bermejo F https://openalex.org/A5014597754 American Medical Association American Medical Association Acute Ischemic Stroke Management Epidemiology Medicine Health Sciences Cerebral embolism Embolism Embolic stroke Internal medicine Cardiology Statement (logic) Transformation (genetics) Event (particle physics) Ischemic stroke Ischemia Philosophy Quantum mechanics Biochemistry Physics Epistemology Gene Chemistry Venous Thromboembolism Diagnosis and Management Intracerebral and Subarachnoid Hemorrhage Research <h3>In Reply.</h3> —We thank Drs Hart and Bogousslavsky for their valuable comments. Regarding Dr Hart's comments we should emphasize that our statement about the low frequency of recurrent emboli was meant for the first three days (in which risk of hemorrhagic transformation is highest). We have studied all the patients admitted with cerebral embolism secondary to RHD since our first series was concluded. There were 19 patients. In ten patients anticoagulants were administered after 48 to 72 hours, and no recurrent embolic events occurred in this short period before treatment. However, in one case a systemic embolism occurred 24 hours prior to the cerebral embolic event. We were surprised by the frequency of hemorrhagic transformation in our first series, but not by the fact that such an event correlated with clinical worsening. There is evidence¹that hemorrhagic transformation in anticoagulated patients (quite similar to spontaneous transformation) is often accompanied by neurologic http://purl.org/coar/access_right/c_16ec

oai:impactu.colav.co:6a457e8f5418a51e32f79132 2026-07-01T20:54:39Z

http://purl.org/coar/resource_type/c_46ec FR 1996-10-02 36 6 382 3 10.1001/archneur.1979.00500420092015 1538-3687 0003-9942 https://openalex.org/W454239 Silve Jean Marc https://openalex.org/A5014742017 American Medical Association American Medical Association Recycling and Waste Management Techniques Industrial and Manufacturing Engineering Environmental Science Physical Sciences Physics Humanities Art Electromagnetic wave absorption materials Delayed radiation necrosis of the brain was found around the right ear in a patient with basal cell carcinoma of the skin. Five months after excision, the tumor recurred. The patient received 5,575 rads in 24 doses during radiotherapy. Thirteen months later, the patient had cerebral radionecrosis, which was the cause of death. At autopsy, typical radionecrotic lesions of the temporal lobe were found. There were widespread metastases. http://purl.org/coar/access_right/c_16ec

oai:impactu.colav.co:6a457e8f5418a51e32f79133 2026-07-03T06:21:20Z

http://purl.org/coar/resource_type/c_6501 EN 1980-07-01 134 7 649 649 10.1001/archpedi.1980.02130190017005 https://pubmed.ncbi.nlm.nih.gov/7395825 0002-922X 2374-3018 https://openalex.org/W1977310571 Yunis Emilio https://openalex.org/A5108500291 RNA modifications and cancer Molecular Biology Biochemistry, Genetics and Molecular Biology Life Sciences Phalanx Medicine Hypoplasia Proximal phalanx Anatomy Dysostosis Brachydactyly Aplasia Polydactyly Consanguinity Surgery Congenital disease Pediatrics Short stature RNA Research and Splicing Nuclear Structure and Function Five patients from three families have a new genetic syndrome. The features include cleidocranial dysostosis, bilateral absence of the thumbs and of the distal phalanges of the fingers, hypoplasia of the first metatarsus, absence of the distal phalanx and hypoplasia of the proximal phalanx of the big toe, pelvic dysplasia, bilateral hip dislocation, a constant facial dysmorphism with sparse hair, peculiar ears, severe micrognathism, and retracted and poorly delineated lips. The existence of consanguinity in two of the families, both with two affected siblings, as well as the lack of sex predilection, allow us to postulate that this syndrome is inherited in a recessive manner. http://purl.org/coar/access_right/c_16ec

oai:impactu.colav.co:6a457e8f5418a51e32f79134 2026-07-03T06:21:20Z

http://purl.org/coar/resource_type/c_6501 EN 2002-11-01 156 11 1101 1101 10.1001/archpedi.156.11.1101 https://pubmed.ncbi.nlm.nih.gov/12413337 1072-4710 1538-3628 https://openalex.org/W1986076928 Brook David W https://orcid.org/0000-0002-8978-8601 https://openalex.org/A5034695491 Brook Judith S https://openalex.org/A5109055785 Pahl Tine https://openalex.org/A5058528525 Montoya Ivan D https://orcid.org/0000-0002-0555-418X https://scholar.google.com/citations?user=K0LQpVwAAAAJ https://openalex.org/A5049237815 American Medical Association American Medical Association Adolescent Sexual and Reproductive Health General Health Professions Health Professions Health Sciences Moderation Psychology Pregnancy Ethnic group Longitudinal study Developmental psychology Human sexuality Demography Drug Clinical psychology Sexual behavior Medicine Psychiatry Social psychology Biology Sociology Genetics Gender studies Pathology Anthropology Prenatal Substance Exposure Effects HIV/AIDS Research and Interventions Reducing adolescent drug use may also reduce levels of risky sexual behavior and early pregnancy and vice versa. Furthermore, the importance of addressing violence as a risk factor for both problem behaviors is emphasized. http://purl.org/coar/access_right/c_16ec

oai:impactu.colav.co:6a457e8f5418a51e32f79135 2026-07-03T06:21:20Z

http://purl.org/coar/resource_type/c_6501 EN 2005-09-01 123 9 1177 1177 10.1001/archopht.123.9.1177 https://pubmed.ncbi.nlm.nih.gov/16157797 1538-3601 0003-9950 https://openalex.org/W2030545004 Ott Elyssa https://orcid.org/0000-0002-4090-8959 https://openalex.org/A5023503974 American Medical Association American Medical Association Glaucoma and retinal disorders Ophthalmology Medicine Health Sciences Dorzolamide Intraocular pressure Timolol Glaucoma Randomized controlled trial Adverse effect Anesthesia Placebo Ocular hypertension Surgery Internal medicine Pathology Alternative medicine Retinal Diseases and Treatments Drug-Induced Ocular Toxicity Dorzolamide was generally well tolerated and demonstrated efficacy for up to 3 months in patients younger than 6 years. http://purl.org/coar/access_right/c_16ec

oai:impactu.colav.co:6a457e8f5418a51e32f79136 2026-07-03T06:21:20Z

http://purl.org/coar/resource_type/c_6501 EN 1983-11-01 143 11 2093 2093 10.1001/archinte.1983.00350110079019 https://pubmed.ncbi.nlm.nih.gov/6357131 0003-9926 1538-3679 https://openalex.org/W2057214650 Bryan Charles S https://orcid.org/0000-0002-9329-7215 https://openalex.org/A5070049160 American Medical Association American Medical Association Streptococcal Infections and Treatments Public Health, Environmental and Occupational Health Medicine Health Sciences Bacteremia Proteus mirabilis Staphylococcus aureus Internal medicine Microbiology Antibiotics Bacteria Biology Genetics Antimicrobial Resistance in Staphylococcus Bacterial Identification and Susceptibility Testing We studied 104 episodes of bacteremia in 102 patients with decubitus ulcers observed over five years in the hospitals of one metropolitan area. The ulcers were considered to be the "probable" source of bacteremia in 49% of episodes. Another site of infection was documented in 86% of patients. Proteus mirabilis, Staphylococcus aureus, and Escherichia coli were the most frequent blood isolates in these patients, but only Bacteroides species correlated with "probable" origin of bacteremia from the ulcers. The overall mortality was 55%, with 51% of deaths being attributed to infection. These findings emphasize the importance of decubitus ulcers as potential sources of bacteremia in hospitalized patients. http://purl.org/coar/access_right/c_16ec

oai:impactu.colav.co:6a457e8f5418a51e32f79137 2026-07-03T06:21:20Z

http://purl.org/coar/resource_type/c_6501 EN 1998-02-01 134 2 143 143 10.1001/archderm.134.2.143 https://pubmed.ncbi.nlm.nih.gov/9487205 0003-987X 1538-3652 https://openalex.org/W2145808750 Jaramillo‐Ayerbe Felipe https://openalex.org/A5043273994 Berrío Muñoz Joaquín https://openalex.org/A5053234211 American Medical Association American Medical Association Dermatological diseases and infestations Infectious Diseases Medicine Health Sciences Dermatology Buttocks Ivermectin Hyperkeratosis Scabies Papule Morphea Surgery Veterinary medicine Lesion Lichen sclerosus Insects and Parasite Interactions An 11-year-old girl from a rural area was referred to our institution for a generalized dermatologic condition diagnosed as seborrheic dermatitis or psoriasis. The disease began 3 years earlier as pruritic lesions on her abdomen and buttocks. The patient had received multiple topical treatments for 3 years; the treatments had consisted of mainly fluorinated corticosteroids prescribed by general practitioners and pharmacy attendants. The intense pruritus caused by her lesions was mitigated transiently by the use of corticosteroids, but the lesions progressively worsened to the point that, at consultation, the patient walked with pain and difficulty and was not able to feed, dress, or clean herself. All family members with whom the patient lived had developed pruritic skin lesions in the previous few months. On examination, the patient was in acceptable general condition but with widespread lesions. There were erythematous and desquamative plaques on her scalp, auricular regions, axillae, and umbilicus; hyperkeratotic and fissured plaques on her palms, soles, elbows, and sacral region; and hyperkeratotic nodules on the dorsa of her hands and feet (Figure 1). Her nails were markedly dystrophic with hyperkeratosis of the hyponychia. There was also a myriad of excoriated papules on her trunk and extremities. The patient experienced severe pain when walking and standing, as well as with flexion and extension of her hands. A diagnosis of crusted Norwegian scabies (CS) was confirmed by scrapings from several skin sites that yielded a huge number of mites, eggs, and fecal pellets (Figure2). Human immunodeficiency virus antibody test results were negative, and except for a slight peripheral eosinophilic leukocytosis (8%), routine laboratory values were within normal limits. Initial treatment consisted of lindane lotion for the patient and her relatives. The symptoms of the family members rapidly resolved, but despite additional therapy with several regimens of topical permethrin and keratolytics, the patient’s lesions failed to achieve any significant improvement. THERAPEUTIC CHALLENGE http://purl.org/coar/access_right/c_abf2 https://jamanetwork.com/journals/jamadermatology/articlepdf/188805/dce7008.pdf application/pdf

oai:impactu.colav.co:6a457e8f5418a51e32f79138 2026-07-03T06:21:20Z

http://purl.org/coar/resource_type/c_0857 EN 1978-07-01 35 7 905 905 10.1001/archpsyc.1978.01770310111012 https://pubmed.ncbi.nlm.nih.gov/354553 0003-990X 1538-3636 https://openalex.org/W1974910437 León Carlos https://openalex.org/A5103418977 Schizophrenia research and treatment Psychiatry and Mental health Medicine Health Sciences Clozapine Anticholinergic Antipsychotic Chlorpromazine Antipsychotic drug Tricyclic Schizophrenia (object-oriented programming) Cohort Perphenazine Psychiatry Psychology Pharmacology Internal medicine <i>To the Editor.—</i>There are relatively few reports as yet in the American literature on the efficacy of clozapine. I am reporting on a three-year case history follow-up of 37 schizophrenic patients (out of an initial cohort of 50) who had participated in a doubleblind, hospital-based drug trial of clozapine vs chlorpromazine for a sixweek period.¹Clozapine (chloro-methylpiperazinyl-dibenzo-diazepine) is of interest because it is a derivative of the diabenzapines (related to the tricyclic compounds) that has been found to have antipsychotic properties, although pharmacologically it does not behave like a neuroleptic.²It has been shown to be practically free of extrapyramidal effects since it is essentially an anticholinergic.^3,4 The initial report requires expansion since it did not emphasize sufficiently the fact that the clozapine capsules mistakenly contained a dose double that which was initially planned. Hence, the mean daily dosage for both drugs fluctuated around 600 mg. http://purl.org/coar/access_right/c_16ec

oai:impactu.colav.co:6a457e8f5418a51e32f79139 2026-07-03T06:21:20Z

http://purl.org/coar/resource_type/c_6501 EN 2022-06-01 24 6 E483 488 10.1001/amajethics.2022.483 https://pubmed.ncbi.nlm.nih.gov/35713916 2376-6980 https://openalex.org/W4283068951 Reynolds Christopher W https://orcid.org/0000-0001-6634-391X https://openalex.org/A5103232865 Sánchez Meertens Camilo https://openalex.org/A5090338084 American Medical Association American Medical Association Torture, Ethics, and Law Sociology and Political Science Social Sciences Ex parte Health care Political science Ex-ante Medicine Criminology Psychology Law Economics Macroeconomics Global Peace and Security Dynamics Health and Conflict Studies Clinicians in postconflict health care settings can be tasked with caring for patients who are ex-combatants. This commentary responds to a case of a health worker with duties to care for ex-Revolutionary Armed Forces of Colombia combatants. Specifically, this article considers clinical, ethical, and legal demands of reincorporating ex-combatants in compliance with a peace agreement on systems and individual health workers. http://purl.org/coar/access_right/c_abf2 https://journalofethics.ama-assn.org/sites/journalofethics.ama-assn.org/files/2022-05/cscm5-peer-2206_1.pdf application/pdf

oai:impactu.colav.co:6a457e8f5418a51e32f7913a 2026-07-03T06:21:20Z

http://purl.org/coar/resource_type/c_efa0 EN 2007-01-01 9 1 12 18 10.1001/archfaci.9.1.12 https://pubmed.ncbi.nlm.nih.gov/17224482 1521-2491 1538-3660 https://openalex.org/W2107139704 Pedroza Fernando https://openalex.org/A5067202194 Gomes Patrocı́Nio Lucas https://orcid.org/0000-0002-3148-9633 https://openalex.org/A5055854638 Arevalo Osiris https://openalex.org/A5014021736 Nasal Surgery and Airway Studies Surgery Medicine Health Sciences Perforation Nasal septum Nose Metallurgy Punching Materials science Head and Neck Surgical Oncology Reconstructive Facial Surgery Techniques The senior author's SP repair technique is easily accomplished, provides good visualization, and is low in cost. Also, in our experience, the success rate of closure has been 97%. http://purl.org/coar/access_right/c_16ec

oai:impactu.colav.co:6a457e8f5418a51e32f7913b 2026-07-03T06:21:20Z

http://purl.org/coar/resource_type/c_6501 EN 1960-10-15 174 7 889 889 10.1001/jama.1960.63030070011020 https://pubmed.ncbi.nlm.nih.gov/13697354 1538-3598 0098-7484 https://openalex.org/W2055111186 Esguerra Fajardo Alfonso https://orcid.org/0000-0003-2677-3469 https://openalex.org/A5084987099 American Medical Association American Medical Association Medical Imaging and Pathology Studies Pulmonary and Respiratory Medicine Medicine Health Sciences Carbonic anhydrase Pulmonary disease Asymptomatic Pathology Etiology Internal medicine Biochemistry Enzyme Chemistry Restraint-Related Deaths Thyroid and Parathyroid Surgery Pulmonary alveolar microlithiasis is a rare disease, there being only 50 or 60 cases described in the medical literature. Since, as a rule, persons with this condition are completely asymptomatic, the diagnosis is usually made after a routine radiographic examination of the thorax. The disease is characterized by the presence of microliths of calcium carbonate and phosphate free in the pulmonary alveoli. A roentgenogram of such lungs usually shows numerous small calcifications about the size of grains of sand distributed through all of the bronchial ramifications. The etiology of microlithiasis is unknown, but it seems reasonable to assume that the disease results from a disturbance in the metabolism of carbon dioxide. As a result, the medium at the surface of the alveoli becomes more alkaline, which favors the precipitation of the microliths. The most comprehensive review of this disease is that written by Sosman and others¹in 1957. These http://purl.org/coar/access_right/c_16ec

oai:impactu.colav.co:6a457e8f5418a51e32f7913c 2026-07-01T20:54:38Z

http://purl.org/coar/resource_type/c_6501 EN 2009-09-01 11 5 347 349 10.1001/archfaci.2009.59 1521-2491 1538-3660 https://openalex.org/W4255524858 Hediyati Reksodiputro Mirta https://orcid.org/0000-0002-5926-5033 https://openalex.org/A5027156718 Koento Trimartani https://orcid.org/0000-0002-2399-0583 https://openalex.org/A5052753829 Boedhihartono https://openalex.org/A5088171536 Sclafani Anthony P https://orcid.org/0000-0001-7875-4847 https://openalex.org/A5038278648 Cleft Lip and Palate Research Genetics Biochemistry, Genetics and Molecular Biology Life Sciences Medicine Anthropometry Orthodontics Surgery Internal medicine Nasal Surgery and Airway Studies http://purl.org/coar/access_right/c_16ec

oai:impactu.colav.co:6a457e8f5418a51e32f7913d 2026-07-03T06:21:20Z

http://purl.org/coar/resource_type/c_6501 EN 1994-03-01 112 3 336 336 10.1001/archopht.1994.01090150066025 https://pubmed.ncbi.nlm.nih.gov/8129658 1538-3601 0003-9950 https://openalex.org/W2165439232 Barraquer C https://openalex.org/A5112158893 American Medical Association American Medical Association Retinal and Macular Surgery Radiology, Nuclear Medicine and Imaging Medicine Health Sciences Retinal detachment Incidence (geometry) Capsulotomy Ophthalmology Surgery Retinal Posterior Capsulotomy Retrospective cohort study Eye disease Retina Lens (geology) Intraocular lens Optics Physics Intraocular Surgery and Lenses Ophthalmology and Visual Impairment Studies Retinal detachment developed in 12 eyes (7.3%) an average (SD) of 30.7 +/- 26.6 months postoperatively; the mean age of these patients was 34 years. We found a clear association between postoperative YAG laser/surgical posterior capsulotomy and the incidence of retinal detachment (11% vs 5.5%) but no association between intraoperative rupture of the posterior capsule and the ultimate incidence of retinal detachment. The retina was reattached in nine cases (75%). http://purl.org/coar/access_right/c_16ec

oai:impactu.colav.co:6a457e8f5418a51e32f7913e 2026-07-03T06:21:20Z

http://purl.org/coar/resource_type/c_6501 DE 1984-10-01 102 10 1519 1519 10.1001/archopht.1984.01040031239027 https://pubmed.ncbi.nlm.nih.gov/6487118 1538-3601 0003-9950 https://openalex.org/W2032989006 Nicholson Don H https://openalex.org/A5110050959 American Medical Association American Medical Association Ocular Diseases and Behçet’s Syndrome Ophthalmology Medicine Health Sciences Retina Glaucoma Pathology Retinal Inflammation Retinal detachment Biology Internal medicine Neuroscience Retinal Diseases and Treatments Retinal and Macular Surgery Ophthalmoscopic evidence of Criswick-Schepens syndrome was found in nine of 22 members of a Colombian family. Histopathologic study of an affected eye enucleated because of neovascular glaucoma showed a focal, nodular zone of fibrovascular proliferation, necrosis, and acute inflammation within the temporal preequatorial retina associated with dense preretinal fibrous organization. Although the cause of the inflammation and cicatrization is unknown, such a nidus may explain some of the advanced clinical manifestations of the syndrome, including temporal dragging of the retina and falciform retinal fold. http://purl.org/coar/access_right/c_16ec

oai:impactu.colav.co:6a457e8f5418a51e32f7913f 2026-07-03T06:21:20Z

http://purl.org/coar/resource_type/c_0857 EN 1979-04-01 36 4 254 254 10.1001/archneur.1979.00500400108026 https://pubmed.ncbi.nlm.nih.gov/426675 1538-3687 0003-9942 https://openalex.org/W2016463248 Vergara Itziar https://orcid.org/0000-0001-9671-7898 https://openalex.org/A5057187259 Toro G. Román Gustavo https://orcid.org/0000-0002-5429-445X https://openalex.org/A5102930901 Mendoza Gabriel https://openalex.org/A5112210329 American Medical Association American Medical Association Peripheral Neuropathies and Disorders Neurology Medicine Health Sciences Guillain-Barre syndrome Vaccination Pediatrics Virology Hereditary Neurological Disorders Botulinum Toxin and Related Neurological Disorders To the Editor.— Shortly before publication in theArchivesof our article titled Neuroparalytic Accidents of Antirabies Vaccination With Suckling Mouse Brain (SMB) Rabies Vaccine (34:694-700, 1977), we had the opportunity to study a new fatal case of Guillain-Barre syndrome. Report of a Case.— A 71-year-old man received seven subcutaneous doses of SMB rabies vaccine for postexposure prophylaxis. The symptoms appeared six days after termination of the vaccination and the clinical picture was characterized by facial diplegia, bulbar muscle involvement, and descending quadriplegia with generalized areflexia. Cerebrospinal fluid values were normal with a slight increase of the IgG level (0.72 mg/dl). The patient was treated with high doses of corticoids and required respiratory assistance from the second day of evolution. Two weeks after the onset of the symptoms, the patient died suddenly. Autopsy was not performed. Virological studies of the vaccine batch were done with negative results. Encephalitogenic activity of http://purl.org/coar/access_right/c_16ec

oai:impactu.colav.co:6a457e8f5418a51e32f79140 2026-07-03T06:21:20Z

http://purl.org/coar/resource_type/c_6501 EN 1984-02-01 41 2 208 209 10.1001/archneur.1984.04050140106037 https://pubmed.ncbi.nlm.nih.gov/6691827 1538-3687 0003-9942 https://openalex.org/W2118161298 Gobernado J https://openalex.org/A5029665814 Lousa M https://openalex.org/A5058038475 Gimeno A https://openalex.org/A5111636505 Gonsalvez M https://openalex.org/A5007763974 American Medical Association American Medical Association Mitochondrial Function and Pathology Molecular Biology Biochemistry, Genetics and Molecular Biology Life Sciences Flavoprotein Mitochondrion Mitochondrial disease Nicotinamide adenine dinucleotide Biochemistry Electron transport chain Organelle Chemistry NAD+ kinase Biology Internal medicine Endocrinology Enzyme Medicine Mitochondrial DNA Gene Cellular transport and secretion Endoplasmic Reticulum Stress and Disease We performed biochemical studies on isolated mitochondria from a muscle biopsy specimen in a patient with Lowe's syndrome. Respiratory controls of mitochondrial preparations with substrates reducing nicotinamide adenine dinucleotide and with a flavoprotein-linked substrate were markedly diminished, but the oxygen consumption was normal with ascorbate and tetramethylphenylenediamine as substrates, which suggested a defect in electron transport prior to the cytochromes. The organelles also showed decreased adenosine diphosphate phosphorylate-oxygen ratio, indicating a partial uncoupling. These findings suggest that Lowe's syndrome could be considered a mitochondrial disease. http://purl.org/coar/access_right/c_16ec

oai:impactu.colav.co:6a457e8f5418a51e32f79141 2026-07-04T12:25:57Z

http://purl.org/coar/resource_type/c_6501 EN 2004-09-27 12 Spec No 412 9 https://pubmed.ncbi.nlm.nih.gov/15303196 https://openalex.org/W1528356877 González Consuegra Renata Virginia https://orcid.org/0000-0001-9269-7789 36489287700 https://openalex.org/A5017863409 https://openalex.org/A5103414705 https://openalex.org/A5110549343 https://scholar.google.com/citations?user=RzhIURoAAAAJ Fontão Zago Márcia María https://orcid.org/0000-0001-6539-2584 https://openalex.org/A5043876282 Health and Lifestyle Studies General Health Professions Health Professions Health Sciences Tobacco use Thematic analysis Health promotion Promotion (chess) Sample (material) Qualitative research Psychology Advertising Medicine Environmental health Sociology Business Nursing Public health Political science Social science Politics Chemistry Population Law Chromatography Global Public Health Policies and Epidemiology The present investigation by means of boarding quanti-qualitative, identifies the beliefs of tobacco consumers, users of a program of promotion of the cardiovascular health in the city of Bogotá-Colombia. The information harvesting became from recorded interviews in depth of 15 persons of the promotion group, who voluntarily constituted the provisory sample until obtaining the thematic saturation of the issue one. The data were analysed and the results considered by the culture. We obtained with it a large description of motivations and discouraging factors for the tobacco smoking. http://purl.org/coar/access_right/c_16ec

oai:impactu.colav.co:6a457e8f5418a51e32f79142 2026-07-03T06:21:20Z

http://purl.org/coar/resource_type/c_6501 RO 1997-06-01 54 6 741 744 10.1001/archneur.1997.00550180055012 https://pubmed.ncbi.nlm.nih.gov/9193209 1538-3687 0003-9942 https://openalex.org/W2102855427 Yoon Byeol‐A https://orcid.org/0000-0002-4350-3551 https://openalex.org/A5065413579 Morillo Carlos A https://orcid.org/0000-0002-8739-2099 https://scholar.google.com/citations?user=2fjTN5oAAAAJ https://openalex.org/A5088254871 https://scholar.google.com/citations?user=EvNXRrIAAAAJ Cechetto David F https://openalex.org/A5059300906 Hachinski Vladimir https://orcid.org/0000-0002-0487-734X https://openalex.org/A5082852366 American Medical Association American Medical Association Heart Rate Variability and Autonomic Control Cardiology and Cardiovascular Medicine Medicine Health Sciences Amobarbital Lateralization of brain function Laterality Cardiology Internal medicine Epilepsy Heart rate variability Balance (ability) Anesthesia Psychology Heart rate Blood pressure Audiology Physical therapy Psychiatry Cardiovascular Syncope and Autonomic Disorders EEG and Brain-Computer Interfaces These findings suggest that there is a cerebral lateralization in cardiac autonomic control and that the right cerebral hemisphere predominantly modulates sympathetic activity. This study may help identify subgroups of patients with intracranial disease at high risk of cardiac complications. http://purl.org/coar/access_right/c_16ec

oai:impactu.colav.co:6a457e8f5418a51e32f79143 2026-07-03T06:21:19Z

http://purl.org/coar/resource_type/c_0857 EN 1984-10-01 41 10 1022 1022 10.1001/archneur.1984.04050210016003 https://pubmed.ncbi.nlm.nih.gov/6477207 1538-3687 0003-9942 https://openalex.org/W2076206678 Gómez Jesús https://openalex.org/A5111823373 Ramos Sanchez Eduardo Milton https://orcid.org/0000-0001-8700-5469 https://openalex.org/A5078854258 Pardo Turriago Rodrigo https://orcid.org/0000-0002-6558-9915 https://openalex.org/A5020998064 https://openalex.org/A5072020339 https://scholar.google.com/citations?user=Jh_Kd-kAAAAJ American Medical Association American Medical Association Parasitic infections in humans and animals Pathology and Forensic Medicine Medicine Health Sciences Praziquantel Cysticercosis Neurocysticercosis Cestode infections Virology Immunology Helminths Pediatrics Pathology Schistosomiasis Parasites and Host Interactions To the Editor. —Two recent reports 1,2 have cast some doubts on the efficacy of praziquantel in the treatment of neurocysticercosis. Because this disease is an important neurosurgical problem in Latin America, we wish to report briefly on our experience with this drug. The introduction of computed tomography (CT) and immunofluorescence have greatly expanded our diagnostic capability with this disease at about the same time that praziquantel, a synthetic acylated isoquinoline-pirazine derivative, graduated from veterinary to human use. During the past three years, we have treated 47 patients with cysticercosis of the CNS. The initial clinical signs and symptoms consisted of increased intracranial pressure in ten patients, epileptiform seizures in 28 patients, mental changes in five patients, combinations of the above in three patients, and ocular manifestations in one patient. All of these patients tolerated the praziquantel therapy well, with the following complications being observed: mental changes in three patients http://purl.org/coar/access_right/c_16ec

oai:impactu.colav.co:6a457e8f5418a51e32f79144 2026-07-01T20:54:39Z

http://purl.org/coar/resource_type/c_6501 ES 2001-01-01 105 10 102 107 10.1001/archpedi.1963.02080040611011 https://openalex.org/W13989437 Guerra Ruiz https://openalex.org/A5058093010 José Robinson https://openalex.org/A5068011258 Organizational Management and Innovation Organizational Behavior and Human Resource Management Business, Management and Accounting Social Sciences Political science Humanities Philosophy Business, Education, Mathematics Research http://purl.org/coar/access_right/c_16ec

oai:impactu.colav.co:6a457e8f5418a51e32f79145 2026-07-03T06:21:20Z

http://purl.org/coar/resource_type/c_6501 EN 1979-11-01 36 11 721 722 10.1001/archneur.1979.00500470091022 https://pubmed.ncbi.nlm.nih.gov/508394 1538-3687 0003-9942 https://openalex.org/W4255938271 Stark Richard https://orcid.org/0000-0002-1637-9700 https://openalex.org/A5039333995 American Medical Association American Medical Association Eosinophilic Disorders and Syndromes Rheumatology Medicine Health Sciences Polymyositis Myositis Prednisolone Muscle biopsy Eosinophilic Internal medicine Myocarditis Pathology Eosinophil Biopsy Gastroenterology Cardiology Asthma Inflammatory Myopathies and Dermatomyositis A case of eosinophilic polymyositis is reported. Tender muscle swelling was followed by proximal weakness, creatinine kinase elevation, and electromyographic features typical of polymyositis. Severe myocarditis, pericarditis and heart failure were present. Muscle biopsy specimen showed active myositis with eosinophil infiltrate. Unlike previous cases, blood eosinophils count was normal. The clinical response to corticosteroids was excellent, and a relapse occurring as steroid dose was lowered responded rapidly to an increased dose of prednisolone. Eosinophilic polymyositis may be a component of a general systemic illness with prominent cardiac involvement. http://purl.org/coar/access_right/c_16ec

oai:impactu.colav.co:6a457e8f5418a51e32f79146 2026-07-03T06:21:20Z

http://purl.org/coar/resource_type/c_6501 EN 1999-05-01 153 5 457 64 10.1001/archpedi.153.5.457 https://pubmed.ncbi.nlm.nih.gov/10323624 1072-4710 1538-3628 https://openalex.org/W1968023072 Brook Judith S https://openalex.org/A5109055785 Brook David W https://orcid.org/0000-0002-8978-8601 https://openalex.org/A5034695491 De La Rosa Mario https://orcid.org/0000-0001-6503-6029 https://scholar.google.com/citations?user=59I-9C8AAAAJ https://openalex.org/A5042275110 Whiteman Martin https://openalex.org/A5051797364 Montoya Ivan D https://orcid.org/0000-0002-0555-418X https://scholar.google.com/citations?user=K0LQpVwAAAAJ https://openalex.org/A5049237815 American Medical Association American Medical Association Child and Adolescent Psychosocial and Emotional Development Clinical Psychology Psychology Social Sciences Juvenile delinquency Deviance (statistics) Poison control Psychological intervention Human factors and ergonomics Personality Injury prevention Adolescent health Suicide prevention Sensation seeking Developmental psychology Clinical psychology Environmental health Social psychology Psychiatry Medicine Nursing Statistics Mathematics Substance Abuse Treatment and Outcomes Youth Development and Social Support The findings have implications for public health policy related to interventions in countries in which violence and drug use are prevalent. The results point to interventional procedures aimed at adolescents vulnerable to marijuana use and delinquency as well as efforts aimed at specific vulnerabilities in these areas. For example, reducing the risk factors and enhancing the protective factors for marijuana use and delinquency may result in less adolescent marijuana use and delinquency. http://purl.org/coar/access_right/c_16ec

oai:impactu.colav.co:6a457e8f5418a51e32f79147 2026-07-03T06:21:20Z

http://purl.org/coar/resource_type/c_6501 EN 2009-08-01 127 8 1006 1006 10.1001/archophthalmol.2009.174 https://pubmed.ncbi.nlm.nih.gov/19667337 1538-3601 0003-9950 https://openalex.org/W2130230865 Cuenca Rojas Adriana Patricia https://orcid.org/0000-0003-3274-885X https://openalex.org/A5054930604 American Medical Association American Medical Association Ocular Oncology and Treatments Ophthalmology Medicine Health Sciences Chemotherapy Radiation therapy Retinoblastoma Metastasis Optic nerve Surgery Regimen Cancer Internal medicine Biology Biochemistry Gene Head and Neck Surgical Oncology Glioma Diagnosis and Treatment Microscopic scleral invasion might be a risk factor for extraocular relapse, and more intensive chemotherapy results in improved survival for these patients. http://purl.org/coar/access_right/c_16ec

oai:impactu.colav.co:6a457e8f5418a51e32f79148 2026-07-01T20:54:39Z

http://purl.org/coar/resource_type/c_6501 EN 2024-06-10 81 8 886 886 10.1001/jamaneurol.2024.1601 https://pubmed.ncbi.nlm.nih.gov/38857022 2168-6157 2168-6149 https://openalex.org/W4399491295 Eduardo Navarro Cristian https://orcid.org/0000-0003-0532-6301 https://openalex.org/A5018068182 American Medical Association American Medical Association Neurosurgical Procedures and Complications Neurology Medicine Health Sciences Calcification Dura mater Calcinosis Anatomy Radiology Trigeminal Neuralgia and Treatments Meningioma and schwannoma management This case report describes a woman with bilateral orbital and frontal throbbing pain with stabbing exacerbations and dystrophic calcification of dura mater and arachnoid granulations. http://purl.org/coar/access_right/c_16ec

oai:impactu.colav.co:6a457e8f5418a51e32f79149 2026-07-04T00:15:45Z

http://purl.org/coar/resource_type/c_6501 EN 2004-12-01 139 12 1278 1278 10.1001/archsurg.139.12.1278 https://pubmed.ncbi.nlm.nih.gov/15611450 0004-0010 1538-3644 https://openalex.org/W2017728352 Morales Uribe Carlos Hernando https://orcid.org/0000-0002-8339-2059 https://openalex.org/A5013087616 https://openalex.org/A5089236194 American Medical Association American Medical Association Abdominal Trauma and Injuries Surgery Medicine Health Sciences Abdominal trauma Univariate analysis Logistic regression Trauma center Prospective cohort study Incidence (geometry) Blunt Referral Risk factor Complication Multivariate analysis Internal medicine Retrospective cohort study Optics Family medicine Physics Appendicitis Diagnosis and Management Abdominal Surgery and Complications The development of intra-abdominal infection in patients undergoing operation because of abdominal trauma is a complex phenomenon resulting from the multiple risk factors during the preoperative, intraoperative, and postoperative periods. Multivariate logistic regression analysis allowed us to identify an Abdominal Trauma Index greater than 24, contamination of the abdominal cavity, and admission to the intensive care unit as independent risk factors for the development of organ/space surgical site infection. http://purl.org/coar/access_right/c_16ec

oai:impactu.colav.co:6a457e8f5418a51e32f7914a 2026-07-01T20:54:39Z

http://purl.org/coar/resource_type/c_6501 EN 2023-07-01 10.0904/jisst.2023705141 https://openalex.org/W4387151899 Ferreira Jocirei https://orcid.org/0000-0001-7479-3056 https://openalex.org/A5023978015 Aranda Lozano Diego Fernando https://orcid.org/0000-0002-0303-9088 23988640100 https://openalex.org/A5103838360 https://openalex.org/A5112216421 https://scholar.google.com/citations?user=Ans2t5EAAAAJ Trejos Angel Deccy Yaneth https://orcid.org/0000-0001-7586-9091 https://openalex.org/A5018559602 Hari Rao V Sree https://openalex.org/A5114086285 Vector-borne infectious diseases Parasitology Immunology and Microbiology Life Sciences Babesiosis Tick Virology Biology Babesia Insect and Pesticide Research Insect Pest Control Strategies In a recent research, a five dimensional ordinary differential equation model describing the transmission of babesiosis disease between bovine and tick populations has been studied. Self-diffusion, modeling the spatial dynamics of the babesiosis disease, is incorporated in the ordinary differential equation model. The normalized version of the proposed model, where the unknown functions are the proportions of the susceptible, infected, and controlled individuals in the total population is analyzed. The main results presented in this work are the local linear stability analysis for the spatially homogeneous equilibrium points, and the global stability of both, the disease-free and endemic equilibria when the proposed model is restricted to inside of the first octant. Finally, numerical simulations presented in this research support our theoretical results and help one to predict some scenarios on the spread of the disease. http://purl.org/coar/access_right/c_abf2 https://zenodo.org/record/8385124 application/pdf

oai:impactu.colav.co:6a457e8f5418a51e32f7914b 2026-07-01T20:54:04Z

http://purl.org/coar/resource_type/c_6501 EN 2007-03-01 27 1 110 5 https://pubmed.ncbi.nlm.nih.gov/17546228 https://openalex.org/W2148416570 Franco Ospina Luis Alberto https://orcid.org/0000-0003-2983-0836 22937622200 https://openalex.org/A5101451432 https://scholar.google.com/citations?user=xWgTGB8AAAAJ Matiz Melo German Eduardo https://orcid.org/0000-0002-2800-6872 https://openalex.org/A5033648183 Calle Jairo https://openalex.org/A5086607997 Pinzón Roberto https://openalex.org/A5005995398 Fernando Ospina Luís https://openalex.org/A5111494746 Phytochemicals and Medicinal Plants Complementary and alternative medicine Medicine Health Sciences Physalis Chemistry Column chromatography Traditional medicine Pharmacognosy Ethyl acetate Carrageenan Antimycobacterial Anti-inflammatory Phytotherapy Pharmacology Biological activity Chromatography Biochemistry In vitro Tuberculosis Pathology Mycobacterium tuberculosis Alternative medicine Pharmacological Effects of Medicinal Plants Essential Oils and Antimicrobial Activity The antiinflammatory activity attributed to Physalis peruviana calyces was confirmed and validated its use in folk medicine. Fractions responsible for the antiinflammatory action were identified and seem promising for phytomedicinal development. Further studies are needed to isolate and identify the active constituents of these fractions as well as to ascertain the mechanisms involved in the antiinflammatory effect. http://purl.org/coar/access_right/c_16ec

oai:impactu.colav.co:6a457e8f5418a51e32f7914c 2026-07-03T06:21:20Z

http://purl.org/coar/resource_type/c_6501 EN 1970-08-01 126 2 272 275 10.1001/archinte.126.2.272 0003-9926 1538-3679 https://openalex.org/W4252595182 Yunis A A https://openalex.org/A5008352461 American Medical Association American Medical Association Mitochondrial Function and Pathology Molecular Biology Biochemistry, Genetics and Molecular Biology Life Sciences Chloramphenicol Mitochondrion Bone marrow Ultrastructure Protein biosynthesis Mitochondrial matrix Drug Cell biology Biology Chemistry Biochemistry Pharmacology Immunology Enzyme Antibiotics Anatomy Cytosol Metabolism and Genetic Disorders Metabolomics and Mass Spectrometry Studies Chloramphenicol is a potent inhibitor of mitochondrial protein synthesis. Recent studies on rabbit and human bone marrow mitochondria strongly suggest a relationship between inhibition of protein synthesis and myelotoxicity from chloramphenicol. A thorough electron microscopic study of bone marrow mitochondria derived from patients receiving chloramphenicol indicates that this drug induces ultrastructural modifications resulting in an increase in the density of the mitochondrial matrix. Excellent correlation is observed between the extent of the ultrastructural changes and serum levels of free chloramphenicol. The results lend further support to the hypothesis that reversible bone marrow suppression from chloramphenicol results from inhibition by the drug of mitochondrial protein synthesis. http://purl.org/coar/access_right/c_16ec

oai:impactu.colav.co:6a457e8f5418a51e32f7914d 2026-07-03T06:21:20Z

http://purl.org/coar/resource_type/c_6501 EN 1974-08-05 229 6 676 676 10.1001/jama.1974.03230440034026 https://pubmed.ncbi.nlm.nih.gov/4277429 1538-3598 0098-7484 https://openalex.org/W1981873869 Hayek Alberto https://orcid.org/0009-0009-7736-5503 https://openalex.org/A5090226966 American Medical Association American Medical Association Parkinson's Disease and Spinal Disorders Neurology Medicine Health Sciences Diabetes insipidus Diabetes mellitus Internal medicine Pediatrics Endocrinology Glycogen Storage Diseases and Myoclonus Neurological and metabolic disorders Two patients developed diabetes insipidus during or following the administration of demeclocycline hydrochloride. The data suggest that this antibiotic interferes with the action of antidiuretic hormone in the renal tubule. Both patients recovered their urinary concentrating ability one week after therapy was discontinued. (<i>JAMA</i>229:676-677, 1974) http://purl.org/coar/access_right/c_16ec

oai:impactu.colav.co:6a457e8f5418a51e32f7914e 2026-07-04T19:06:21Z

http://purl.org/coar/resource_type/c_6501 EN 2008-06-01 134 6 603 603 10.1001/archotol.134.6.603 https://pubmed.ncbi.nlm.nih.gov/18559726 0886-4470 1538-361X https://openalex.org/W2149874084 Sanabria Quiroga Alvaro Enrique https://orcid.org/0000-0002-5563-8840 16178863700 https://openalex.org/A5029934678 https://scholar.google.com/citations?user=Y7nWYkAAAAAJ Carvalho André Lopes https://orcid.org/0000-0001-7214-6402 https://scholar.google.com/citations?user=i4fLNUcAAAAJ https://openalex.org/A5011385272 Guilherme Vartanian José https://orcid.org/0000-0003-1995-6742 https://openalex.org/A5010014584 Magrin José https://openalex.org/A5109930924 Ikeda Mauro Kasuo https://openalex.org/A5108515906 Kowalski Luiz Paulo https://scholar.google.com/citations?user=9A0498QAAAAJ https://openalex.org/A5047897878 American Medical Association American Medical Association Head and Neck Cancer Studies Otorhinolaryngology Medicine Health Sciences Comorbidity Cohort Internal medicine Head and neck cancer Population Cohort study Cancer Physical therapy Environmental health ancianos cirugia de cabeza y cuello Epidemiologia clinica Chronic Disease Management Strategies The WUHNCI did not demonstrate good discriminative power compared with the ACE-27 in a cohort of older patients. To be widely used, instruments developed to measure comorbidities must be reliable in any population. We believe that the ACE-27 is still the best index to assess comorbidities and that it should be used in studies evaluating the prognostic effect of comorbidities. http://purl.org/coar/access_right/c_16ec

oai:impactu.colav.co:6a457e8f5418a51e32f7914f 2026-07-03T06:21:20Z

http://purl.org/coar/resource_type/c_6501 EN 2003-10-01 121 10 1439 1439 10.1001/archopht.121.10.1439 https://pubmed.ncbi.nlm.nih.gov/14557180 1538-3601 0003-9950 https://openalex.org/W2152885823 Serrano Juan https://openalex.org/A5089259763 American Medical Association American Medical Association Traumatic Ocular and Foreign Body Injuries Ophthalmology Medicine Health Sciences Epidemiology Visual acuity Eye injuries Referral Blunt Injury prevention Childhood blindness Emergency department Poison control Medical record Pediatrics Visual impairment Surgery Emergency medicine Retinopathy of prematurity Family medicine Internal medicine Gestational age Biology Psychiatry Genetics Pregnancy Restraint-Related Deaths Facial Trauma and Fracture Management Most of the accidents reported in this study could have been avoided; the data demonstrate a clear need for primary prevention and control measures. http://purl.org/coar/access_right/c_16ec

oai:impactu.colav.co:6a457e8f5418a51e32f79150 2026-07-01T20:54:39Z

http://purl.org/coar/resource_type/c_b239 EN 1997-03-19 277 11 881 882 10.1001/jama.277.11.881 https://pubmed.ncbi.nlm.nih.gov/2878181 1538-3598 0098-7484 https://openalex.org/W4251540011 reyes ortiz Carlos Alfonso https://orcid.org/0000-0001-7983-7791 https://openalex.org/A5100759804 https://openalex.org/A5103676422 https://scholar.google.com/citations?user=rrE-Yg4AAAAJ American Medical Association American Medical Association Selenium in Biological Systems Nutrition and Dietetics Nursing Health Sciences Medicine Adverse effect Incidence (geometry) Selenium Placebo Disease Urinary incontinence Urinary system Clinical trial Internal medicine Intensive care medicine Surgery Alternative medicine Materials science Physics Optics Pathology Metallurgy Kidney Stones and Urolithiasis Treatments Ureteral procedures and complications <h3>In Reply.</h3> —We share Dr Herbert's concern regarding the safety of using 200 μg of selenium in a high-selenium brewer's yeast and have been concerned about documenting both adverse and beneficial health effects of selenium supplementation, especially those that could only be identified in a doubleblind, placebo-controlled trial. The choice of a nutritional dose diminished the safety issues in the trial and was based on the upper limit of the US Estimated Safe and Adequate Intake of selenium.¹ The trial's Safety Monitoring Committee reviewed the incidence of patient-reported disease and did not identify any significant adverse health events associated with selenium supplementation. The trial eligibility criteria excluded patients with active liver and kidney disease; however, we have not identified any additional groups of patients in the trial who were at particular risk of adverse health events. For safety reasons, pregnant women were also excluded from active participation. While there may be http://purl.org/coar/access_right/c_16ec

oai:impactu.colav.co:6a457e8f5418a51e32f79151 2026-07-04T19:22:57Z

http://purl.org/coar/resource_type/c_6501 EN 2001-10-01 136 10 1131 1131 10.1001/archsurg.136.10.1131 https://pubmed.ncbi.nlm.nih.gov/11585504 0004-0010 1538-3644 https://openalex.org/W2058913118 Morales Uribe Carlos Hernando https://orcid.org/0000-0002-8339-2059 https://openalex.org/A5013087616 https://openalex.org/A5089236194 Villegas Lanau Maria Isabel https://openalex.org/A5086407195 American Medical Association American Medical Association Pleural and Pulmonary Diseases Pulmonary and Respiratory Medicine Medicine Health Sciences Stab wound Laparotomy Thoracoscopy Diaphragmatic breathing Surgery Diaphragm (acoustics) Stab Gold standard (test) Penetrating trauma Lesion Radiology Blunt Pathology Loudspeaker Alternative medicine Acoustics Physics Trauma toracoabdominal herida diafragma diagnóstico exploración digital Trauma Management and Diagnosis Congenital Diaphragmatic Hernia Studies Digital exploration is a reliable method for the detection of injuries to the left side of the diaphragm caused by stab wounds. http://purl.org/coar/access_right/c_16ec

oai:impactu.colav.co:6a457e8f5418a51e32f79152 2026-07-04T12:07:13Z

http://purl.org/coar/resource_type/c_0857 EN 2017-02-27 171 4 398 398 10.1001/jamapediatrics.2016.5157 https://pubmed.ncbi.nlm.nih.gov/28241249 2168-6211 2168-6203 https://openalex.org/W2594177486 Andrés García‐Perdomo Herney https://orcid.org/0000-0001-6945-8261 https://openalex.org/A5078242740 Cárdenas Calle Juan Pablo https://openalex.org/A5108761703 garcia perdomo Herney Andres 35368443300 https://openalex.org/A5016884809 https://openalex.org/A5041267284 https://openalex.org/A5078561151 https://scholar.google.com/citations?user=N8LOryoAAAAJ American Medical Association American Medical Association Kawasaki Disease and Coronary Complications Surgery Medicine Health Sciences Kawasaki disease Adjunctive treatment Pediatrics Primary (astronomy) Internal medicine Artery Astronomy Physics Mechanical Circulatory Support Devices Streptococcal Infections and Treatments Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Pediatrics HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Pediatrics journal http://purl.org/coar/access_right/c_16ec

oai:impactu.colav.co:6a457e8f5418a51e32f79153 2026-07-03T06:21:20Z

http://purl.org/coar/resource_type/c_6501 EN 1963-04-01 86 4 544 544 10.1001/archsurg.1963.01310100028005 https://pubmed.ncbi.nlm.nih.gov/13951122 0004-0010 1538-3644 https://openalex.org/W2042773383 Guerrero Figueroa R https://openalex.org/A5025406004 American Medical Association American Medical Association Diet and metabolism studies Physiology Medicine Health Sciences Catecholamine Secretion Gastric secretion Surgery Internal medicine Recent work of Altamirano and Chiang¹in our laboratory demonstrated that stimulation of the splanchnic nerve and of the gastric sympathetic nerves produces a rise in pepsinogen secretion from the gastric glands, previous to injection of 0.1 mg. histamine per kilogram body weight. Heath et al.^13,15reported marked increase in outpouring of urinary 17-ketosteroids, a significant drop in circulating eosinophils, and an increase of 200% to 300% in total white blood cell count with stimulation to the septal region in rhesus monkeys. After adrenalectomy, changes in these measurements of essentially the same magnitude occurred with repetition of the stimulus to the septal region, suggesting that these indicators of the stress response from brain stimulation were not dependent upon the adrenals. Folkow and von Euler⁵demonstrated that hypothalamic stimulation in the cat induced a secretion of epinephrine and arterenol from the adrenal gland in varying proportions, depending on http://purl.org/coar/access_right/c_16ec

oai:impactu.colav.co:6a457e8f5418a51e32f79154 2026-07-01T20:54:39Z

http://purl.org/coar/resource_type/c_6501 EN 1994-03-09 271 10 727 727 10.1001/jama.1994.03510340005001 1538-3598 0098-7484 https://openalex.org/W2048193132 De Roux Gustavo I https://openalex.org/A5054256056 American Medical Association American Medical Association Crime, Illicit Activities, and Governance Sociology and Political Science Social Sciences Medicine Medical emergency Family medicine Terrorism, Counterterrorism, and Political Violence Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue http://purl.org/coar/access_right/c_16ec

oai:impactu.colav.co:6a457e8f5418a51e32f79155 2026-07-03T16:15:59Z

http://purl.org/coar/resource_type/c_6501 EN 2008-05-01 144 5 603 8 10.1001/archderm.144.5.603 https://pubmed.ncbi.nlm.nih.gov/18490586 0003-987X 1538-3652 https://openalex.org/W2088513281 Hicks Lindsey D https://openalex.org/A5002936020 Cook‐Norris Robert H https://openalex.org/A5072275956 Mendoza Natalia https://openalex.org/A5112773438 Madkan Vandana https://openalex.org/A5085175026 Arora Anita https://orcid.org/0000-0002-8035-5826 https://openalex.org/A5102978283 Tyring Stephen K https://orcid.org/0000-0002-3337-0580 https://openalex.org/A5000478173 Norris Robert H Cook American Medical Association American Medical Association Herpesvirus Infections and Treatments Epidemiology Medicine Health Sciences Postherpetic neuralgia Odds ratio Family history Shingles Confidence interval Varicella zoster virus Risk factor Immunosuppression Pediatrics Immunology Internal medicine Virus Pathology Alternative medicine Acne and Rosacea Treatments and Effects Dermatology and Skin Diseases The results suggest an association between herpes zoster and family history of zoster. Future studies will be needed to investigate this association. http://purl.org/coar/access_right/c_16ec

oai:impactu.colav.co:6a457e905418a51e32f79156 2026-07-03T06:21:20Z

http://purl.org/coar/resource_type/c_6501 EN 2006-11-01 8 6 396 403 10.1001/archfaci.8.6.396 1521-2491 1538-3660 https://openalex.org/W2011087015 Pedroza Fernando https://openalex.org/A5067202194 Dos Anjos Gustavo Coelho https://openalex.org/A5045127721 Gomes Patrocı́Nio Lucas https://orcid.org/0000-0002-3148-9633 https://openalex.org/A5055854638 Maria Barreto Jose https://openalex.org/A5024563723 María Cortés J https://openalex.org/A5034848958 Quessep Suad H https://openalex.org/A5059617203 Nasal Surgery and Airway Studies Surgery Medicine Health Sciences Patient satisfaction Nose Reconstructive Facial Surgery Techniques Cleft Lip and Palate Research Objectives: To present and evaluate outcomes with the seagull wing technique, which was designed to replace the lower lateral cartilages and to reconstruct the nasal tip. Methods: The seagull wing technique is illustrated and described in detail. Sixty patients who underwent surgery 1981 and 2002 were retrospectively evaluated. A preoperative diagnosis of tip deformities was made based on photographs, which were compared with the postoperative results. Patient satisfaction was subjectively evaluated. Results: The postoperative results showed a significant statistical improvement in the following tip deformities: underprojected tip ( P &lt;.001), poorly defined tip ( P &lt;.001), alar retraction ( P &lt;.001), alar pinch ( P &lt;.001), overrotated tip ( P &lt;.001), and tip ptosis ( P &lt;.01). The average follow-up period was 14.6 months. Fifty-five patients (92%) stated that they were very satisfied with the surgical results; they required no additional revision surgery. Conclusions: The seagull wing technique is a safe and efficient reconstructive treatment for the aesthetic and functional problems that were caused by the overresection of the nasal tip cartilaginous framework. The outcomes were pleasing, and the results were stable during the follow-up period. Patient satisfaction was high. http://purl.org/coar/access_right/c_16ec

oai:impactu.colav.co:6a457e905418a51e32f79157 2026-07-01T20:54:38Z

http://purl.org/coar/resource_type/c_6501 EN 2007-03-01 27 1 56 65 https://pubmed.ncbi.nlm.nih.gov/17546224 https://openalex.org/W2034704724 Moreno Niño Olga María https://orcid.org/0000-0002-0826-6191 22938513300 https://openalex.org/A5102000752 https://openalex.org/A5113894252 González Rugeles Clara Isabel https://orcid.org/0000-0002-0278-1512 https://openalex.org/A5049669588 https://scholar.google.com/citations?user=r2L1v1UAAAAJ Luis Saaibi Diego https://openalex.org/A5017179193 Otero Regino William Alberto https://orcid.org/0000-0002-6825-9014 https://openalex.org/A5012793012 https://openalex.org/A5063812038 https://openalex.org/A5077222883 https://openalex.org/A5089755287 Badillo Reynaldo https://scholar.google.com/citations?user=UiFI4D0AAAAJ https://openalex.org/A5024047497 Martín Javier https://orcid.org/0000-0002-2202-0622 https://scholar.google.com/citations?user=j-lW-IEAAAAJ https://openalex.org/A5069412319 https://scholar.google.com/citations?user=cjgk2esAAAAJ Ramírez Gerardo https://openalex.org/A5044170321 Rheumatoid Arthritis Research and Therapies Rheumatology Medicine Health Sciences Rheumatoid arthritis Rheumatoid factor Immunology Arthritis Population Haplotype Linkage disequilibrium Genotype Internal medicine Gastroenterology Biology Genetics Gene Environmental health Systemic Lupus Erythematosus Research Autoimmune and Inflammatory Disorders Research Interleukin-10 is an important regulator of the immune response and likely plays a role in the pathogenesis of rheumatoid arthritis. The current results suggested that Interleukin-10 promoter polymorphisms were not important for development or severity of rheumatoid arthritis. http://purl.org/coar/access_right/c_16ec

oai:impactu.colav.co:6a457e905418a51e32f79158 2026-07-03T06:21:20Z

http://purl.org/coar/resource_type/c_0857 EN 1988-03-01 45 3 244 245 10.1001/archneur.1988.00520270014008 https://pubmed.ncbi.nlm.nih.gov/2829802 1538-3687 0003-9942 https://openalex.org/W1978636761 Román Gustavo https://orcid.org/0000-0002-5429-445X https://openalex.org/A5102930901 Román Lydia https://openalex.org/A5108602335 Sever John L https://openalex.org/A5109099337 Madden David L https://openalex.org/A5017501990 Schoenberg Bruce S https://openalex.org/A5108250262 Saravia Gomez Jaime https://openalex.org/A5098114514 American Medical Association American Medical Association T-cell and Retrovirus Studies Immunology Immunology and Microbiology Life Sciences Tropical spastic paraparesis Medicine Antibody Virology Serology Spasticity Virus Internal medicine Myelopathy Spinal cord Physical therapy Psychiatry Vector-Borne Animal Diseases <h3>To the Editor.</h3> —Recent reports^1,2indicate the presence of positive human T-lymphotropic virus type I (HTLV-I) antibodies in the cerebrospinal fluid of 16 (73% ) of 22 subjects, and in 94% of the serum samples of Colombian patients with tropical spastic paraparesis (TSP). In a previous neuroepidemiologic study,³we have shown clustering of TSP cases in the southern Pacific lowlands in Colombia, mainly around the port town of Tuma co. However, there are no prevalence studies of HTLV-I or adult T-cell leukemia and non-Hodgkin's lymphoma from Colombia. For this reason, we studied serum samples from blood donors at the San Juan de Dios University Hospital in Bogotá. <h3>Materials and Methods.</h3> —Serum samples from 145 adult blood donors were frozen and transported in dry ice to the Immunochemistry and Clinical Investigations Section, Infectious Disease Branch, National Institute of Neurological Communicative Disorders and Stroke, National Institutes of Health, Bethesda, Md. Serum http://purl.org/coar/access_right/c_16ec

oai:impactu.colav.co:6a457e905418a51e32f79159 2026-07-04T12:28:23Z

http://purl.org/coar/resource_type/c_6501 EN 1996-01-01 38 4 289 302 10.1002/(sici)1098-2345(1996)38:4<289::aid-ajp1>3.0.co;2-v https://pubmed.ncbi.nlm.nih.gov/31918484 0275-2565 1098-2345 https://openalex.org/W2062891556 Defler Thomas Richard https://orcid.org/0000-0001-8846-5328 https://openalex.org/A5042060150 https://scholar.google.com/citations?user=yhUp0ngAAAAJ John Wiley &amp; Sons Inc. John Wiley &amp; Sons Inc. Primate Behavior and Ecology Social Psychology Psychology Social Sciences Home range Range (aeronautics) Ecology Demography Biology Amazon rainforest Geography Habitat Composite material Materials science Sociology Wildlife Ecology and Conservation Animal Vocal Communication and Behavior A group of woolly monkeys (Lagothrix lagothricha), studied for 1,800 hr from June 1984 until September 1987 in the eastern Colombian Amazon, used a home range of about 760 ha, 90% of which overlapped the ranges of three other groups. Home range use varied throughout the year, correlating in part with variations in fruit production. The home range exhibited a nonexclusive "core area" in the floristically most diverse part of the home range, although the majority of the home range was entered at a much lower frequency. Within the study area woolly monkeys occurred at a density of 5.5 individuals/km². The average day range was 2,880 m, and the average straight line distance between sleeping sites was 896 m. Day ranges differed significantly across months, but the only significant correlation tested was a positive relation with time spent "moving" in the activity budget. Comparisons with three other Amazonian sites where woolly monkeys have been studied reveal considerable variation. Soil fertility, plant community differences, and other factors seem to influence ranging patterns. © 1996 Wiley-Liss, Inc. http://purl.org/coar/access_right/c_16ec

oai:impactu.colav.co:6a457e905418a51e32f7915a 2026-07-03T06:21:20Z

http://purl.org/coar/resource_type/c_6501 EN 2020-07-01 156 8 916 916 10.1001/jamadermatol.2020.1287 https://pubmed.ncbi.nlm.nih.gov/32609323 2168-6068 2168-6084 https://openalex.org/W3039943125 Felix Kayla https://openalex.org/A5109514885 De Souza Brianna https://openalex.org/A5089207929 Portilla Nataly https://orcid.org/0000-0002-0325-7640 https://openalex.org/A5063300363 Hogue Latrice https://openalex.org/A5074647400 Ahn Christine https://orcid.org/0000-0003-3505-7915 https://openalex.org/A5080426767 Sangüeza Omar https://openalex.org/A5052362224 Mcmichael Amy https://openalex.org/A5026470121 American Medical Association American Medical Association Hair Growth and Disorders Urology Medicine Health Sciences Scalp Dermatology Vertex (graph theory) Combinatorics Graph Mathematics Dermatological and Skeletal Disorders Hypertrophic osteoarthropathy and related conditions Central centrifugal cicatricial alopecia (CCCA) is a scarring alopecia commonly seen in African American individuals. 1 It classically affects the vertex scalp, although 1 study 2 suggests that it may manifest as patchy hair loss beyond the vertex. In that study, the histopathologic, dermatoscopic, and clinical findings were crucial in diagnosis. However, another study 3 reported histopathologic changes in the vertex scalp consistent with CCCA even without clinically visible hair loss. Our study explored dermatoscopic and histopathologic findings in areas of the scalp without clinically active disease, specifically beyond the vertex scalp. We also assessed the reliability of dermatoscopy, which may serve as a less invasive diagnostic tool than biopsy, for the diagnosis of CCCA in the context of subclinical disease. http://purl.org/coar/access_right/c_abf2 https://jamanetwork.com/journals/jamadermatology/articlepdf/2767657/jamadermatology_felix_2020_ld_200010.pdf application/pdf

oai:impactu.colav.co:6a457e905418a51e32f7915b 2026-07-03T06:21:20Z

http://purl.org/coar/resource_type/c_6501 EN 1997-07-23 278 4 287 288 10.1001/jama.278.4.287 1538-3598 0098-7484 https://openalex.org/W4240436727 reyes ortiz Carlos Alfonso https://orcid.org/0000-0001-7983-7791 https://openalex.org/A5100759804 https://openalex.org/A5103676422 https://scholar.google.com/citations?user=rrE-Yg4AAAAJ American Medical Association American Medical Association Health and Well-being Studies Clinical Psychology Psychology Social Sciences Medicine Delirium Dehydration Intensive care medicine Gerontology Psychiatry Biochemistry Chemistry Thermoregulation and physiological responses Intensive Care Unit Cognitive Disorders To the Editor.—The article by Dr Ferrucci and colleagues' on catastrophic and progressive disability helps physicians to understand the disability process in older persons. However, dehydration and cognitive impairment need more emphasis. First, Ferrucci et al found that dehydration was an important diagnosis in the disability subsets. Dehydration was 1 of the 6 most frequent discharge diagnoses among both men and women who developed progressive disability, and its cumulative percentage was similar to that of pneumonia and http://purl.org/coar/access_right/c_16ec

oai:impactu.colav.co:6a457e905418a51e32f7915c 2026-07-03T06:21:20Z

http://purl.org/coar/resource_type/c_6501 EN 1999-11-01 58 3 387 395 10.1002/(sici)1097-4547(19991101)58:3<387::aid-jnr4>3.3.co;2-c 1097-4547 0360-4012 https://openalex.org/W4253170603 Marzolo María‐Paz https://orcid.org/0000-0002-2328-2464 https://openalex.org/A5049694880 Von Bernhardi Rommy https://orcid.org/0000-0002-9022-7676 https://scholar.google.com/citations?user=_-9D_40AAAAJ https://openalex.org/A5044094653 Inestrosa Nibaldo https://orcid.org/0000-0003-3118-9726 https://openalex.org/A5040876102 Wiley-Liss Inc. Wiley-Liss Inc. Neuroinflammation and Neurodegeneration Mechanisms Neurology Neuroscience Life Sciences Mannose Mannose receptor Microglia Receptor Cell biology Chemistry Computational biology Biology Immunology Biochemistry Inflammation In vitro Macrophage We studied the expression of the mannose receptor (ManR) in rat microglial cells. Microglial cells are the central nervous system resident macrophages, key participants of the innate immune response. ManR is a differentiation marker and a relevant glycoprotein for the phagocytic and endocytic function of macrophages. Because there is evidence suggesting that ManR could mediate some of the nonenzymatic effects of acetilcholinesterase (AchE) and the enzyme seems to be involved in Alzheimer's disease (AD), we looked for ManR in http://purl.org/coar/access_right/c_16ec

oai:impactu.colav.co:6a457e905418a51e32f7915d 2026-07-01T20:54:39Z

http://purl.org/coar/resource_type/c_6501 EN 2006-10-01 134 10 1302 5 https://pubmed.ncbi.nlm.nih.gov/17186101 https://openalex.org/W1594576062 Vitriol Verónica https://openalex.org/A5066196217 Gomberoff Mario https://openalex.org/A5009745999 Elena Basualto María https://openalex.org/A5017435211 Ballesteros Soledad https://orcid.org/0000-0002-9199-3110 https://openalex.org/A5103169179 Child Abuse and Trauma Clinical Psychology Psychology Social Sciences Psychopathology Sexual abuse Anxiety Psychiatry Child sexual abuse Daughter Psychological intervention Child abuse Clinical psychology Medicine Poison control Injury prevention Medical emergency Evolutionary biology Biology Child and Adolescent Psychosocial and Emotional Development Child Welfare and Adoption There is a relationship between child sexual abuse and adult psychopathology. We report a 35 year-old woman derived to the Psychiatric Service of the Curicó Hospital due to anxiety and depressive symptoms lasting eight years, to illustrate the above mentioned relationship. At the psychiatric unit, a post traumatic stress disorder of belated onset, triggered by sexual abuse during childhood, re-edited after her daughter's birth, was diagnosed. This case illustrates different factors, which, in retrospective studies, have been associated with the morbid consequences of child sexual abuse, and allows an understanding of how different sexually traumatic events, during a person's lifetime, contribute to the development of a psychopathology. The problem was confronted by the mental health team at different levels and symptoms subsided in few interventions. An active search of the traumatic sexual background, allowed this achievement. The importance of studying and validating clinical situations as the present case, with methodologies based on evidence, is stressed. http://purl.org/coar/access_right/c_16ec

oai:impactu.colav.co:6a457e905418a51e32f7915e 2026-07-03T06:21:20Z

http://purl.org/coar/resource_type/c_6501 PT 1999-01-01 35 1 83 84 10.1002/(sici)1520-6696(199924)35:1<83::aid-jhbs30>3.0.co;2-7 0022-5061 1520-6696 https://openalex.org/W2616470537 Morgado Pereira Jos� https://openalex.org/A5103751725 John Wiley &amp; Sons Inc. John Wiley &amp; Sons Inc. Psychology and Mental Health Clinical Psychology Psychology Social Sciences Citation Humanities Library science Sociology Art Computer science What we have finally got is a work somewhat different from what has been widely expected.“Monsters”, as such, do not figure in the title and occupy only a chapter of the book. This may be because other scholars have meanwhile produced fine studies of changing models of monstrosity—amongst books, one thinks of Dudley Wilson's Signs and Portents: http://purl.org/coar/access_right/c_16ec

oai:impactu.colav.co:6a457e905418a51e32f7915f 2026-07-04T17:53:00Z

http://purl.org/coar/resource_type/c_6501 EN 1999-01-01 71 2 121 132 10.1002/(sici)1097-461x(1999)71:2<121::aid-qua1>3.0.co;2-z 1097-461X 0020-7608 https://openalex.org/W2054901548 Moyano Gloria Esperanza https://orcid.org/0000-0002-1241-9381 6602902491 https://openalex.org/A5069814110 https://scholar.google.com/citations?user=3U-s-9wAAAAJ Villaveces Jos� https://openalex.org/A5103486446 Villaveces Cardoso Jose Luis https://openalex.org/A5103515880 John Wiley &amp; Sons Inc. John Wiley &amp; Sons Inc. Spectroscopy and Quantum Chemical Studies Atomic and Molecular Physics, and Optics Physics and Astronomy Physical Sciences Hamiltonian (control theory) Wave function Basis (linear algebra) Distribution function Distribution (mathematics) Space (punctuation) Physics Quantum mechanics Statistical physics Mathematical physics Computational chemistry Mathematics Mathematical analysis Chemistry Computer science Geometry Operating system Mathematical optimization Quantum Mechanics and Non-Hermitian Physics Quantum Information and Cryptography In order to obtain wave functions, energies, and energy derivatives for molecular systems, we present a general approximation procedure based on distribution theory. We found in the testing functions space of distribution theory, an appropriate mathematical basis to overcome theoretical difficulties related with the standard perturbational method in which the Born–Huang proposal is supported and that have been worked unsuccessfully until now. Specifically, we refer to two problems: the separation between nuclear and electronic coordinates and the existence of expansions convergent toward ground-state wave functions. Using generalized functions and their properties, we begin by proving that the expectation value of electronic energy for molecules are analytic functions of the nuclear coordinates. We show that this result could be expressed in a particular set of 3N−6 internal coordinates. We also obtain new expressions for energy derivatives. These developments are made for the nonrelativistic Schrödinger Hamiltonian. ©1999 John Wiley & Sons, Inc. Int J Quant Chem 71: 121–132, 1999 http://purl.org/coar/access_right/c_16ec

oai:impactu.colav.co:6a457e905418a51e32f79160 2026-07-04T19:17:37Z

http://purl.org/coar/resource_type/c_6501 EN 1999-07-01 135 7 804 10 10.1001/archderm.135.7.804 https://pubmed.ncbi.nlm.nih.gov/10411155 0003-987X 1538-3652 https://openalex.org/W2164554436 rueda plata Ricardo Augusto https://orcid.org/0000-0002-9236-9627 https://openalex.org/A5046174669 https://openalex.org/A5065533735 https://scholar.google.com/citations?user=klDmjjoAAAAJ Valencia Isabel https://orcid.org/0000-0002-2695-8044 https://openalex.org/A5014489099 Covelli Claudia https://orcid.org/0000-0001-7158-059X https://openalex.org/A5020201657 Escobar Carlos https://openalex.org/A5084243264 Alzate Alberto https://openalex.org/A5111838046 Saldarriaga Tellez Bladimir https://openalex.org/A5022666344 https://openalex.org/A5024880224 https://openalex.org/A5109598226 Sanclemente Mesa Gloria https://orcid.org/0000-0002-1555-2751 https://openalex.org/A5023620667 Blank A https://openalex.org/A5108487717 Falabella Rafael https://openalex.org/A5036793477 American Medical Association American Medical Association Eosinophilic Disorders and Syndromes Rheumatology Medicine Health Sciences Radiation therapy Pathology Eosinophilic Eosinophilia Biopsy Dermatology Histopathology Cancer Internal medicine EPPER radiotherapy eosinophils cancer Cutaneous lymphoproliferative disorders research Vascular Tumors and Angiosarcomas The clinical, histopathological, and immunopathologic features in patients with cancer undergoing radiotherapy are described. To our knowledge, this condition has not been well characterized. Because of its unique presentation, the denomination "eosinophilic, polymorphic, and pruritic eruption associated with radiotherapy" is suggested. http://purl.org/coar/access_right/c_16ec

oai:impactu.colav.co:6a457e905418a51e32f79161 2026-07-03T06:21:20Z

http://purl.org/coar/resource_type/c_6501 EN 1964-12-01 89 6 936 936 10.1001/archsurg.1964.01320060004002 https://pubmed.ncbi.nlm.nih.gov/14208465 0004-0010 1538-3644 https://openalex.org/W4250326966 Cobo Alex https://openalex.org/A5070472542 American Medical Association American Medical Association Pediatric Hepatobiliary Diseases and Treatments Surgery Medicine Health Sciences Incidence (geometry) Intrahepatic bile ducts Autopsy Gastroenterology Internal medicine General surgery Bile duct Optics Physics Gallbladder and Bile Duct Disorders Pancreatitis Pathology and Treatment Lithiasis in the larger intrahepatic bile ducts can lead to partial or complete obstruction of biliary flow. In the University Hospital in Cali, Colombia, one third of the patients with persistent common duct stones were found to have intrahepatic calculi. Because this cause of persistent stones has seldom been emphasized,^8,19,25study of this condition in patients at Universidad del Valle was undertaken in an effort to elucidate the problem. The present study includes patients in whom most of the stones were located above the junction of the right and left hepatic ducts. <h3>Incidence.</h3> —The incidence of intrahepatic calculi is difficult to estimate.^{3,6,9,13,18,29}Several careful analyses of extensive series of autopsies and of patients operated on for cholelithiasis contain no reference to incidence.^1,2,11,21Best,⁵in a review of pertinent publications up to 1944, found an incidence of 7.6% among 456 collected cases of cholelithiasis studied at autopsy. http://purl.org/coar/access_right/c_16ec

oai:impactu.colav.co:6a457e905418a51e32f79162 2026-07-04T18:54:22Z

http://purl.org/coar/resource_type/c_6501 EN 1997-03-12 277 10 793 793 10.1001/jama.1997.03540340027028 https://pubmed.ncbi.nlm.nih.gov/9052708 0098-7484 1538-3598 https://openalex.org/W2110985141 Lopera Restrepo Francisco Javier https://orcid.org/0000-0003-3986-1484 https://openalex.org/A5024744959 https://openalex.org/A5068500999 Ruiz Linares Andres Martinez Alonso https://orcid.org/0000-0003-3619-6087 https://openalex.org/A5074883658 https://scholar.google.com/citations?user=qm5syr8AAAAJ Arango Lasprilla Juan Carlos https://orcid.org/0000-0002-7184-8311 https://openalex.org/A5041271816 https://scholar.google.com/citations?user=EsZ9s74AAAAJ Kosik Kenneth Madrigal Zapata Zapata Lucia del Socorro Ossa Londono Jorge Eliecer Arcos Burgos Oscar Mauricio https://openalex.org/A5040664560 https://openalex.org/A5042004652 https://openalex.org/A5098175111 https://scholar.google.com/citations?user=MZlwFqgAAAAJ Arango Viana Juan Carlos https://orcid.org/0000-0003-0017-402X https://openalex.org/A5055018602 https://scholar.google.com/citations?user=_tZg6lwAAAAJ American Medical Association American Medical Association Alzheimer's disease research and treatments Physiology Medicine Health Sciences Presenilin Pediatrics Age of onset Disease Family history Population Alzheimer's disease Internal medicine Environmental health Presenilin-1 neurodegeneración Mutación E280A Antioquia Colombia Alzheimer Precoz Neurodegeneración E280A mutation Early Alzheimer Disease Onset Demencia presenilin-1 Amyotrophic Lateral Sclerosis Research Parkinson's Disease Mechanisms and Treatments Other than the early onset, this clinical phenotype is indistinguishable from sporadic AD except that affected individuals frequently complained of headache preceding and during the disease. Despite the uniform genetic basis for the disease, there was significant variability in the age at onset, suggesting an important role for environmental factors or genetic modifiers in determining the age at onset. http://purl.org/coar/access_right/c_16ec

oai:impactu.colav.co:6a457e905418a51e32f79163 2026-07-03T06:21:20Z

http://purl.org/coar/resource_type/c_6501 EN 1996-06-01 275 23 83 94 10.1002/(sici)1097-010x(19960601/15)275:2/3<83::aid-jez3>3.3.co;2-g 0022-104X 1097-010X https://openalex.org/W4246236995 Hamlett W C https://openalex.org/A5059717829 Schwartz F J https://openalex.org/A5001273374 Schmeinda R https://openalex.org/A5009311728 Cuevas E https://openalex.org/A5065966916 John Wiley and Sons Inc John Wiley and Sons Inc Congenital heart defects research Molecular Biology Biochemistry, Genetics and Molecular Biology Life Sciences Chordae tendineae Endocardium Anatomy Sinus venosus Ventricle Basal lamina Biology Histology Sinus (botany) Mitral valve Medicine Internal medicine Botany Ultrastructure Genus Ichthyology and Marine Biology Fish biology, ecology, and behavior We report here on the anatomy, histology, and development of the three sets of cardiac valves in embryonic and adult elasmobranch fishes. The sinus venosus is the first segment of the heart to receive blood, and a pair of sinoatrial (SA) valves prevent backward flow of blood into the sinus venosus. The SA valves derive from two dorsolateral infoldings of the cardiac wall and consist of a simple endocardium covering transverse sheets rich in collagen. The SA valves are simple flaps of tissue without papillary muscles or chordae tendineae. Blood from the atrium passes the atrioventricular (AV; semilunar) valves, which are attached to papillary muscles in the ventricle by way of the chordae tendineae. A series of rows of conal or pocket valves (CV) in the conus arteriosus, equipped with chordae tendineae but no papillary muscles, prevent blood from reentering the ventricle. Chordae tendineae form in a similar fashion in both chambers. Elevations from the chamber wall emerge as a sheet covered on both surfaces with endocardium and separated by a core of connective tissue. Endocardial cells extend basal projections toward the opposing epithelium through their basal laminae. Basal cell projections make contact to create perforations that enlarge to produce spaces between the nascent chordae. Fibroblasts in the core of the chordae enlarge and strengthen the chordae by producing linear arrays of collagen fibers. © 1996 Wiley-Liss, Inc. http://purl.org/coar/access_right/c_16ec eyJjb2xsX2luZGV4IjowLCJsYXN0X2lkIjoiNmE0NTdlOTA1NDE4YTUxZTMyZjc5MTYzIiwic2VydmVkIjoxMDAsInByZWZpeCI6Im9haV9jZXJpZl9vcGVuYWlyZSJ9